Document Detail


Treatment of porphyria cutanea tarda by the effect of chloroquine on the liver.
MedLine Citation:
PMID:  7632437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Porphyria cutanea tarda (PCT) is characterized by cutaneous symptoms in association with hepatic accumulation and urinary excretion of mainly uro- and heptacarboxyporphyrins. 24 PCT patients excreting urinary porphyrins between 1.9 and 5.8 mumol/24 h (normal < 0.2) were treated with chloroquine at a dose of 125 mg twice a week. During the first phase of therapy urinary porphyrin excretion transiently increased 1.1- to 2.9-fold indicating a phase of mobilization. A slight initial elevation was also found regarding the activities of serum aminotransferases reflecting the hepatotoxic effect of chloroquine. The clinical symptoms disappeared after a period ranging from 2 to 6 months, and after an average of 12 months the porphyrin excretion in all patients had returned to nearly normal values.
Authors:
A Freesemann; M Frank; I Sieg; M O Doss
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Skin pharmacology : the official journal of the Skin Pharmacology Society     Volume:  8     ISSN:  1011-0283     ISO Abbreviation:  Skin Pharmacol.     Publication Date:  1995  
Date Detail:
Created Date:  1995-09-11     Completed Date:  1995-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8810069     Medline TA:  Skin Pharmacol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  156-61     Citation Subset:  IM    
Affiliation:
Division of Clinical Biochemistry, Philipps University, Marburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chloroquine / therapeutic use*
Chromatography, High Pressure Liquid
Chronic Disease
Female
Humans
Liver / drug effects,  metabolism*
Liver Function Tests
Male
Middle Aged
Porphyria Cutanea Tarda / drug therapy*,  enzymology
Porphyrins / urine
Spectrophotometry, Ultraviolet
Transaminases / metabolism
Chemical
Reg. No./Substance:
0/Porphyrins; 54-05-7/Chloroquine; EC 2.6.1.-/Transaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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