Document Detail

Treatment of poisoning induced cardiac impairment using cardiopulmonary bypass: a review.
MedLine Citation:
PMID:  16549566     Owner:  NLM     Status:  MEDLINE    
Severe poisoning can cause potentially fatal cardiac depression. Cardiopulmonary bypass (CPB) can support the depressed myocardium, but there are no clear indications or guidelines available on its use in severe poisoning. A review was conducted of relevant papers in the available literature (seven single case reports of both deliberate and accidental ingestion of cardiotoxic drugs and two animal studies). Although CPB is rarely used in the management of poisoning, it may have potential benefits for haemodynamic instability not responding to conventional measures. At present there is insufficient evidence concerning the use of CPB as a treatment for severe cardiac impairment due to poisoning (grade C). This review suggests that in patients with severe and potentially prolonged reversible cardiotoxicity there is potential for full survival with CPB, provided that the patient has not already sustained hypoxic cerebral damage due to resistant hypotension prior to its use.
S Purkayastha; P Bhangoo; T Athanasiou; R Casula; B Glenville; A W Darzi; J A Henry
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Emergency medicine journal : EMJ     Volume:  23     ISSN:  1472-0213     ISO Abbreviation:  Emerg Med J     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-03-21     Completed Date:  2006-04-17     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  100963089     Medline TA:  Emerg Med J     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Department of Biosurgery and Surgical Technology, Imperial College, St Mary's Hospital, London, UK.
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MeSH Terms
Anti-Arrhythmia Agents / poisoning
Cardiopulmonary Bypass*
Child, Preschool
Drug Overdose / therapy
Heart Diseases / chemically induced,  therapy*
Middle Aged
Poisoning / complications*,  therapy
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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