| Treatment of photoaged skin. Efficacy, tolerability and costs of available agents. | |
| | |
MedLine Citation:
|
PMID: 8785463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Photoaging is a cumulative degenerative process induced by solar irradiation with well defined clinical and histological correlates. Because of its huge psychological impact, there is much demand for effective treatment. Many well constructed trials confirm the clinical efficacy of topical tretinoin for improving fine wrinkling and mild to moderate hyperpigmentation; coarse wrinkling and severe hyperpigmentation respond less well. Histological improvement is well documented, but the precise relationship to clinical response is not clearly established. Tolerability can be a problem. Optimal concentrations are not firmly established and vary between patients. Claims that topical isotretinoin is better tolerated than tretinoin need to be confirmed with well constructed trials. Despite many claims, there have been no adequate trials documenting the efficacy of fish cartilage polysaccharide extracts or alpha-hydroxy acids. Careful patient selection with consideration of alternative treatments such as chemical peeling, dermabrasion and surgery is important to successful management of photoaging. |
| | |
Authors:
|
S D Helander |
Related Documents
:
|
18706763 - Analyzing multiple endpoints in clinical trials of pain treatments: immpact recommendat... 4557273 - Clinical and laboratory findings in a trial of norgestrel, a low-dose progestogen-only ... 12888033 - The disruptive effect of chronic pain on mismatch negativity. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Drugs & aging Volume: 8 ISSN: 1170-229X ISO Abbreviation: Drugs Aging Publication Date: 1996 Jan |
Date Detail:
|
Created Date: 1996-09-26 Completed Date: 1996-09-26 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9102074 Medline TA: Drugs Aging Country: NEW ZEALAND |
Other Details:
|
Languages: eng Pagination: 12-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Economics, Pharmaceutical Humans Hydroxy Acids / therapeutic use* Skin Aging / drug effects* Tretinoin / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Hydroxy Acids; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Polymyositis and Sjögren's syndrome associated with bronchiolitis obliterans organizing pneumonia.
Next Document: Optimising thrombolytic therapy in elderly patients with acute myocardial infarction.