| Treatment of persistent corneal epithelial defect by autologous serum application. | |
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MedLine Citation:
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PMID: 10519596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the efficacy of autologous serum application for the treatment of persistent epithelial defect. DESIGN: Prospective, clinical, noncomparative case series. PARTICIPANTS: A total of 16 eyes were studied. INTERVENTION: Autologous serum was prepared from the patients and diluted to 20% by saline. The patients were instructed to use the autologous serum six to ten times a day. The concentration of vitamin A, epidermal growth factor (EGF), and transforming growth factor-beta (TGF-beta) was measured at 1 week and 1 month stored in the refrigerator and 1 month and 3 months in the freezer. MAIN OUTCOME MEASURES: Time to closure of epithelial defect. RESULTS: Vitamin A, EGF, and TGF-beta were stable during the 1 month in the refrigerator and 3 months in the freezer. Among 16 persistent epithelial defects, 7 (43.8%) healed within 2 weeks, 3 (18.8%) healed within 1 month, and the remaining 6 (37.5%) did not respond within 1 month. No apparent side effect of autologous serum application was observed. CONCLUSIONS: Autologous serum application healed 43.8% of persistent defect within 2 weeks and 62.5% within 1 month. |
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Authors:
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K Tsubota; E Goto; S Shimmura; J Shimazaki |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ophthalmology Volume: 106 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 1999 Oct |
Date Detail:
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Created Date: 1999-10-18 Completed Date: 1999-10-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1984-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Oral Health Center, Tokyo Dental College, Ichikawa-shi, Chiba, Japan. kazuo@eyebank.or.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood* Cell Movement Corneal Diseases / etiology, therapy* Dry Eye Syndromes / complications Epidermal Growth Factor / blood Epithelium, Corneal / pathology* Female Humans Male Middle Aged Prospective Studies Transforming Growth Factor beta / blood Vitamin A / blood Wound Healing |
| Chemical | |
Reg. No./Substance:
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0/Transforming Growth Factor beta; 11103-57-4/Vitamin A; 62229-50-9/Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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