| Treatment of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) with intraperitoneal cefazolin and gentamicin. | |
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MedLine Citation:
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PMID: 2488364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1983 and 1988 57 peritonitis episodes in an unselected patient population were initially treated with intraperitoneal cefazolin and gentamicin. The loading dose consisted of 500 mg cefazolin/L dialysate and 40 mg gentamicin/L dialysate. The maintenance dosage was 125 mg cefazolin and 8 mg gentamicin per liter dialysate. Forty-five (78.9%) patients were primarily cured with this regimen (responder group = RG). Twelve patients (21.1%) did not respond to the initial therapy (nonresponder group = NG). Eight peritonitis episodes in the NG (14.0% of all patients) were caused by tunnel infections and 2 by diverticulitis (3.5%). The cure rate in patients without tunnel infection or bowel disease was 95.7%. A relapse occurred in 2 patients (3.5%). Duration of therapy was assessed by daily white blood cell count (WBC) in the effluent and treatment was discontinued when the WBC was less than 100/microliters for 3 days. The mean duration of therapy with cefazolin and gentamicin was 8.1 days in the RG and 6.0 days in the NG. Nonresponders were subsequently treated with a modified antibiotic regimen on an average 11.9 days. |
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Authors:
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J Weber; E Staerz; T Mettang; C Machleidt; U Kuhlmann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 9 ISSN: 0896-8608 ISO Abbreviation: Perit Dial Int Publication Date: 1989 |
Date Detail:
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Created Date: 1991-05-02 Completed Date: 1991-05-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: CANADA |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: IM |
Affiliation:
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Robert Bosch Hospital, Teaching Hospital, Eberhard Karls University Tübingen, West Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catheters, Indwelling Cefazolin / administration & dosage*, therapeutic use Drug Therapy, Combination / therapeutic use Female Gentamicins / administration & dosage*, therapeutic use Humans Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory / adverse effects* Peritonitis / drug therapy*, microbiology Staphylococcal Infections / drug therapy*, etiology Staphylococcus epidermidis / isolation & purification* |
| Chemical | |
Reg. No./Substance:
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0/Gentamicins; 25953-19-9/Cefazolin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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