Document Detail

Treatment of peritonitis in continuous ambulatory peritoneal dialysis (CAPD) with intraperitoneal cefazolin and gentamicin.
MedLine Citation:
PMID:  2488364     Owner:  NLM     Status:  MEDLINE    
Between 1983 and 1988 57 peritonitis episodes in an unselected patient population were initially treated with intraperitoneal cefazolin and gentamicin. The loading dose consisted of 500 mg cefazolin/L dialysate and 40 mg gentamicin/L dialysate. The maintenance dosage was 125 mg cefazolin and 8 mg gentamicin per liter dialysate. Forty-five (78.9%) patients were primarily cured with this regimen (responder group = RG). Twelve patients (21.1%) did not respond to the initial therapy (nonresponder group = NG). Eight peritonitis episodes in the NG (14.0% of all patients) were caused by tunnel infections and 2 by diverticulitis (3.5%). The cure rate in patients without tunnel infection or bowel disease was 95.7%. A relapse occurred in 2 patients (3.5%). Duration of therapy was assessed by daily white blood cell count (WBC) in the effluent and treatment was discontinued when the WBC was less than 100/microliters for 3 days. The mean duration of therapy with cefazolin and gentamicin was 8.1 days in the RG and 6.0 days in the NG. Nonresponders were subsequently treated with a modified antibiotic regimen on an average 11.9 days.
J Weber; E Staerz; T Mettang; C Machleidt; U Kuhlmann
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  9     ISSN:  0896-8608     ISO Abbreviation:  Perit Dial Int     Publication Date:  1989  
Date Detail:
Created Date:  1991-05-02     Completed Date:  1991-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Robert Bosch Hospital, Teaching Hospital, Eberhard Karls University Tübingen, West Germany.
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MeSH Terms
Catheters, Indwelling
Cefazolin / administration & dosage*,  therapeutic use
Drug Therapy, Combination / therapeutic use
Gentamicins / administration & dosage*,  therapeutic use
Middle Aged
Peritoneal Dialysis, Continuous Ambulatory / adverse effects*
Peritonitis / drug therapy*,  microbiology
Staphylococcal Infections / drug therapy*,  etiology
Staphylococcus epidermidis / isolation & purification*
Reg. No./Substance:
0/Gentamicins; 25953-19-9/Cefazolin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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