Document Detail

Treatment of periocular capillary hemangioma with topical clobetasol propionate.
MedLine Citation:
PMID:  9098309     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hemangiomas pose a therapeutic challenge because they can threaten vision in infancy and early childhood. Intralesional injection of corticosteroid is widely regarded as the treatment of choice for hemangiomas which induce strabismus or significant refractive error, or occlude the visual axis. Ocular and systemic complications such as eyelid necrosis, central retinal artery occlusion, and adrenal suppression have been reported rarely after corticosteroid injection. METHODS: Three infants were treated with clobetasol propionate (Temovate) cream for vision-threatening eyelid hemangiomas. RESULTS: Treatment with this topical fluorinated corticosteroid produced a measurable reduction in the size of the hemangiomas, which permitted clearing of the visual axis. No regional side effects were noted. In addition, the patients did not demonstrate evidence of hypothalamic-pituitary-adrenal axis suppression. CONCLUSIONS: This treatment modality appears to provide an additional alternative for managing superficial periocular hemangiomas which threaten vision.
O A Cruz; S R Zarnegar; S E Myers
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Ophthalmology     Volume:  102     ISSN:  0161-6420     ISO Abbreviation:  Ophthalmology     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1997-05-08     Completed Date:  1997-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802443     Medline TA:  Ophthalmology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2012-5     Citation Subset:  IM    
Department of Ophthalmology, Anheuser-Busch Eye Institute, St. Louis University School of Medicine, MO 63104, USA.
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents / adverse effects,  therapeutic use*
Child, Preschool
Clobetasol / adverse effects,  analogs & derivatives*,  therapeutic use
Eyelid Neoplasms / drug therapy*,  pathology
Hemangioma, Capillary / drug therapy*,  pathology
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 0/Ointments; 25122-41-2/Clobetasol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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