| Treatment of patent ductus arteriosus with bidirectional flow in neonates. | |
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MedLine Citation:
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PMID: 21402454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patent ductus arteriosus is a common occurrence among prematurely born neonates and is believed to play a role in the development of other complications of prematurity including intraventricular hemorrhage, bronchopulmonary dysplasia, and necrotizing enterocolitis. The clinical decision to treat the patent ductus arteriosus is complicated by the lack of evidence available regarding clinical conditions under which closure should be attempted. STUDY AIMS: To compare clinical outcomes for neonates who underwent treatment of patent ductus arteriosus exhibiting bidirectional blood flow versus those with flow that was left to right. STUDY DESIGN: Cohort study of all neonates with patent ductus arteriosus in which medical closure was attempted at the Duke University between January 2002 and October 2007. OUTCOME MEASURES: Death and other important clinical conditions. RESULTS: We identified 20 neonates with bidirectional flow out of 317 cases in which medical closure of patent ductus arteriosus was attempted. There was no significant increase in overall complications due to closure of a bidirectional patent ductus arteriosus [40% (8/20)] versus ones with left to right shunting [38% (111/297) p=0.82]. Death occurred in 15% (3/20) with bidirectional PDA compared to 11% (34/297) in the left to right group, p=0.72. CONCLUSION: The trend in mortality is worrisome but does not contraindicate an aggressive approach to the clinically significant PDA that has bidirectional flow at the time of the echocardiogram. |
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Authors:
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Patrick N Ethington; P Brian Smith; Lakshmi Katakam; Ronald N Goldberg; C Michael Cotten |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-03-12 |
Journal Detail:
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Title: Early human development Volume: 87 ISSN: 1872-6232 ISO Abbreviation: Early Hum. Dev. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-18 Completed Date: 2011-08-11 Revised Date: 2011-08-25 |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 381-4 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Pediatrics, Duke University, Durham, NC 27710, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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administration & dosage* Cohort Studies Ductus Arteriosus, Patent / drug therapy*, physiopathology*, ultrasonography Echocardiography Female Humans Ibuprofen / administration & dosage* Indomethacin / administration & dosage* Infant, Newborn Infant, Premature* Male Survival Analysis |
| Grant Support | |
ID/Acronym/Agency:
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1K23HD060040-01/HD/NICHD NIH HHS; K23 HD060040-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 15687-27-1/Ibuprofen; 53-86-1/Indomethacin |
| Comments/Corrections | |
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