| Treatment outcomes and prognostic factors of patients with supratentorial low-grade oligodendroglioma. | |
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MedLine Citation:
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PMID: 12459363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Oligodendroglioma is a relatively rare central nervous system tumor. Currently, surgical intervention is the mainstay of treatment, and the role of postoperative radiotherapy (RT) remains a subject of controversy. The objective of this study was to investigate the prognostic factors, evaluate the treatment outcomes, and assess whether postoperative RT has a benefit on local control and overall survival rates. METHODS AND MATERIALS: This was a retrospective review of 52 consecutive adult patients with supratentorial low-grade oligodendrogliomas diagnosed at our institution between September 1980 and September 1998. Thirty-two received postoperative RT. Data were analyzed retrospectively to survey the significant prognostic factors for local control and overall survival. RESULTS: The 5-year overall and progression-free survival rate was 80% and 67%, respectively. Twenty-five patients experienced local disease progression during the follow-up period. In multivariate analysis, postoperative RT and age at diagnosis showed independent prognostic significance for overall survival. For progression-free survival, postoperative RT was the only independent prognostic factor. CONCLUSION: On the basis of the results of this study, we recommend considering postoperative RT as one of the standard adjuvant treatment modalities for patients with supratentorial low-grade oligodendroglioma, regardless of the extent of surgical resection. The optimal treatment strategy to maximize the treatment outcome should still be explored. |
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Authors:
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Shyh-An Yeh; Tao-Chen Lee; Han-Jung Chen; Chun-Chung Lui; Li-Min Sun; Chong-Jong Wang; Eng-Yen Huang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of radiation oncology, biology, physics Volume: 54 ISSN: 0360-3016 ISO Abbreviation: Int. J. Radiat. Oncol. Biol. Phys. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-12-02 Completed Date: 2003-01-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7603616 Medline TA: Int J Radiat Oncol Biol Phys Country: United States |
Other Details:
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Languages: eng Pagination: 1405-9 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan. yidam@seed.net.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age of Onset Aged Brain Neoplasms / diagnosis, radiotherapy*, surgery* Combined Modality Therapy Disease Progression Disease-Free Survival Female Humans Male Middle Aged Multivariate Analysis Oligodendroglioma / diagnosis, radiotherapy*, surgery* Prognosis Retrospective Studies Time Factors Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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