Document Detail


Treatment outcomes and prognostic factors of patients with supratentorial low-grade oligodendroglioma.
MedLine Citation:
PMID:  12459363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Oligodendroglioma is a relatively rare central nervous system tumor. Currently, surgical intervention is the mainstay of treatment, and the role of postoperative radiotherapy (RT) remains a subject of controversy. The objective of this study was to investigate the prognostic factors, evaluate the treatment outcomes, and assess whether postoperative RT has a benefit on local control and overall survival rates. METHODS AND MATERIALS: This was a retrospective review of 52 consecutive adult patients with supratentorial low-grade oligodendrogliomas diagnosed at our institution between September 1980 and September 1998. Thirty-two received postoperative RT. Data were analyzed retrospectively to survey the significant prognostic factors for local control and overall survival. RESULTS: The 5-year overall and progression-free survival rate was 80% and 67%, respectively. Twenty-five patients experienced local disease progression during the follow-up period. In multivariate analysis, postoperative RT and age at diagnosis showed independent prognostic significance for overall survival. For progression-free survival, postoperative RT was the only independent prognostic factor. CONCLUSION: On the basis of the results of this study, we recommend considering postoperative RT as one of the standard adjuvant treatment modalities for patients with supratentorial low-grade oligodendroglioma, regardless of the extent of surgical resection. The optimal treatment strategy to maximize the treatment outcome should still be explored.
Authors:
Shyh-An Yeh; Tao-Chen Lee; Han-Jung Chen; Chun-Chung Lui; Li-Min Sun; Chong-Jong Wang; Eng-Yen Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation oncology, biology, physics     Volume:  54     ISSN:  0360-3016     ISO Abbreviation:  Int. J. Radiat. Oncol. Biol. Phys.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-02     Completed Date:  2003-01-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7603616     Medline TA:  Int J Radiat Oncol Biol Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1405-9     Citation Subset:  IM    
Affiliation:
Department of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung Hsien, Taiwan. yidam@seed.net.tw
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Brain Neoplasms / diagnosis,  radiotherapy*,  surgery*
Combined Modality Therapy
Disease Progression
Disease-Free Survival
Female
Humans
Male
Middle Aged
Multivariate Analysis
Oligodendroglioma / diagnosis,  radiotherapy*,  surgery*
Prognosis
Retrospective Studies
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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