Document Detail

Treatment of osteonecrosis of the jaw (ONJ) by medical ozone gas insufflation. A case report.
MedLine Citation:
PMID:  22825522     Owner:  NLM     Status:  In-Data-Review    
Osteonecrosis of the jaw (ONJ) is an adverse event reported in patients receiving cancer treatment, especially bisphosphonates and denosumab. A patient with multiple myeloma who underwent up to 22 intravenous zoledronic acid infusions without previous dental examination developed a devastating ONJ lesion in the right horizontal mandibular ramus. He was treated with local ozone gas applications every third day by means of a special bell to avoid O3 diffusion. Azithromycin 500 mg/day was administered for 10 days prior to the O3 applications. O3 therapy resulted in sequestration of the necrotic bone after a median of 15 applications, following which surgery was necessary to remove it. Interestingly, removal was possible without the resection of the healthy mandible edge because of the presence of the bone sequestrum. Medical O3 gas administration was effective and safe in a patient treated with bisphosphonates who developed a >2.5 cm ONJ lesion. Future research is needed to demonstrate the efficacy and tolerability of such treatment in a larger number of patients.
Carla Ida Ripamonti; Massimo Maniezzo; Maria Adelaide Pessi; Stefania Boldini
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tumori     Volume:  98     ISSN:  2038-2529     ISO Abbreviation:  Tumori     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-07-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0111356     Medline TA:  Tumori     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  72e-5e     Citation Subset:  IM    
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