Document Detail

Treatment of osteoarthritis in hypertensive patients.
MedLine Citation:
PMID:  20059368     Owner:  NLM     Status:  MEDLINE    
IMPORTANCE OF THE FIELD: Osteoarthritis and hypertension commonly co-exist. Treatment of osteoarthritis in hypertensive patients is a therapeutic challenge due to the adverse effects of some analgesics, especially non-steroidal anti-inflammatory drugs (NSAIDs), on blood pressure. Even small drug-induced rises in blood pressure due to therapy may significantly increase cardiovascular risk in these patients if sustained over the long term. Patients treated with certain classes of antihypertensive agent may be at particular risk of deterioration in blood pressure control with NSAID therapy. NSAIDs may also increase cardiovascular risk due to mechanisms other than by raising blood pressure. AREAS COVERED IN THIS REVIEW: We discuss the management of osteoarthritis in the hypertensive patient, review the evidence for the effects of paracetamol and NSAIDs on blood pressure and discuss novel therapeutic strategies for osteoarthritis that might diminish this problem. A literature search was undertaken in PubMed including the years 1980 - 2009. WHAT THE READER WILL GAIN: Insight will be gained into the complexity of treating patients with co-existent osteoarthritis and hypertension and into possible new approaches to treating osteoarthritis symptoms effectively in these patients while minimising any adverse impact on blood pressure control. TAKE HOME MESSAGE: There are ways to minimise the adverse impact of treatment of osteoarthritis on blood pressure control in hypertensive patients.
Isla S Mackenzie; Thomas M MacDonald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  11     ISSN:  1744-7666     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  393-403     Citation Subset:  IM    
University of Dundee, Ninewells Hospital, Hypertension Research Centre and Medicines Monitoring Unit, Level 7, Dundee DD1 9SY, UK.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / economics,  therapeutic use*
Antihypertensive Agents / economics,  therapeutic use*
Antirheumatic Agents / economics,  therapeutic use*
Blood Pressure / drug effects*,  physiology
Cost of Illness
Endothelium, Vascular / drug effects
Exercise / physiology
Health Behavior
Hypertension / complications,  drug therapy*
Nitric Oxide / metabolism
Osteoarthritis / drug therapy*,  economics,  etiology
Randomized Controlled Trials as Topic
Risk Assessment
Risk Factors
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antihypertensive Agents; 0/Antirheumatic Agents; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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