Document Detail

Treatment of obstetric and gynecologic infections with cefamandole.
MedLine Citation:
PMID:  426015     Owner:  NLM     Status:  MEDLINE    
Cefamandole nafate is a derivative of 7-aminocephalosporanic acid which has been shown to have good in vitro activity against aerobes traditionally susceptible to cephalosporins as well as many anaerobes, including B. fragilis. One hundred women with obstetric or gynecologic infections completed treatment with cefamandole: 53 had post-cesarean section infections: 24, acute pelvic inflammatory disease: 16, posthysterectomy cuff cellulitis/abscess; and seven, vulvar or abdominal wound abscess. Almost 90% of these women had either polymicrobial aerobic/anaerobic bacterial infections or an anaerobic infection alone. Ninety women responded to cefamandole alone; in 10 cases chloramphenicol was added, but in addition five of these women required surgical therapy for eradication of infection. Mild to severe phlebitis at the infusion site that responded to conservative therapy was demonstrated in 14 women. Of 312 bacterial isolates from these women, 89% were sensitive to cefamandole at 32 microgram/ml, an easily achievable serum level; 93% of anaerobic streptococci, the most common isolates, were sensitive at 32 microgram/ml. Also, 90% of all Bacteroides species were susceptible at 32 microgram/ml; 82% of B. fragilis were susceptible at this concentration. These data indicate that cefamandole is safe and effective for treatment of women with polymicrobial pelvic infections but that approximately 5% of these women will require surgical exploration in addition to antimicrobial administration.
F G Cunningham; L C Gilstrap; S S Kappus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  133     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  602-10     Citation Subset:  AIM; IM    
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MeSH Terms
Abscess / drug therapy
Acute Disease
Bacterial Infections / drug therapy*
Bacteroides Infections / drug therapy
Cefamandole / therapeutic use*
Cellulitis / drug therapy
Cephalosporins / therapeutic use*
Cesarean Section / adverse effects*
Clostridium Infections / drug therapy
Endometritis / drug therapy
Enterobacteriaceae Infections / drug therapy
Genital Diseases, Female / drug therapy*
Hysterectomy / adverse effects*
Peritonitis / drug therapy
Streptococcal Infections / drug therapy
Surgical Wound Infection / drug therapy*
Vulvitis / drug therapy
Reg. No./Substance:
0/Cephalosporins; 34444-01-4/Cefamandole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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