| Treatment of nonfebrile status epilepticus in Rochester, Minn, from 1965 through 1984. | |
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MedLine Citation:
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PMID: 11155411 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the adequacy and efficacy of antiepileptic drug (AED) treatment of nonfebrile status epilepticus (SE). PATIENTS AND METHODS: We performed a population-based retrospective cohort study to evaluate the medical management of SE. Participants included 184 residents of Rochester, Minn, who experienced a first episode of nonfebrile SE between 1965 and 1984. RESULTS: Of the 184 patients, 133 (72.2%) received appropriate, prompt medical treatment for SE, i.e., intravenous diazepam, phenytoin, or phenobarbital. In 100 patients (75.8%), the dose of the first AED administered was less than that currently recommended. The first treatment was effective in terminating SE in 41 (31.1%) of 132 patients. The adequacy of treatment was highly predictive of drug efficacy (P = .002). The dose of the second AED treatment was inadequate in 52 (80%) of 65 patients treated. CONCLUSION: Based on this retrospective study, the treatment of SE is remarkable for both inadequacy and ineffectiveness. The inappropriate use of therapeutic regimens in the management of SE may be an important cause of ineffective medical treatment. |
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Authors:
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G D Cascino; D Hesdorffer; G Logroscino; W A Hauser |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 76 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-11 Completed Date: 2001-01-25 Revised Date: 2007-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: United States |
Other Details:
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Languages: eng Pagination: 39-41 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA. gcascino@mayo.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Anticonvulsants / administration & dosage* Child Child, Preschool Diazepam / administration & dosage Female Humans Infant Infusions, Intravenous Male Middle Aged Phenobarbital / administration & dosage Phenytoin / administration & dosage Retrospective Studies Status Epilepticus / drug therapy* Treatment Failure |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 439-14-5/Diazepam; 50-06-6/Phenobarbital; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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