Document Detail

Treatment of nine cases of pemphigus vulgaris with cyclosporine.
MedLine Citation:
PMID:  3385040     Owner:  NLM     Status:  MEDLINE    
The effects of cyclosporine were studied in nine patients suffering from pemphigus vulgaris. Of four patients treated with cyclosporine alone, only one cleared. Of four corticosteroid-resistant pemphigus vulgaris patients, all improved after cyclosporine addition to corticosteroids. The last patient treated from the beginning with a combined treatment (cyclosporine-corticosteroids) did not respond. The main advantage of using cyclosporine is to allow a decrease in corticosteroid dosages and to permit treating corticosteroid-resistant pemphigus vulgaris patients. No detectable irreversible side effects were noted. The treatment was discontinued in two patients because of reversible side effects. Cyclosporine alone does not seem to be an adequate treatment of the acute phase of pemphigus vulgaris but could be used in addition to corticosteroids. The most important drawback of cyclosporine treatment is the occurrence of clinically silent renal dysfunction (tubular involvement and interstitial fibrosis), which may occur during long-term treatments. More studies need to be carried out to determine the effects of low doses of cyclosporine on renal function in patients who have normal renal functions.
H Barthelemy; A Frappaz; F Cambazard; G Mauduit; B Rouchouse; J Kanitakis; P Souteyrand; A L Claudy; J Thivolet
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  18     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-08-02     Completed Date:  1988-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1262-6     Citation Subset:  IM    
Dermatology Clinic, E. Herriot Hospital, Lyon, France.
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MeSH Terms
Administration, Oral
Cyclosporins / administration & dosage,  adverse effects,  therapeutic use*
Drug Combinations
Middle Aged
Pemphigus / drug therapy*
Prednisone / administration & dosage
Reg. No./Substance:
0/Cyclosporins; 0/Drug Combinations; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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