| Treatment of neurogenic diabetes insipidus. | |
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MedLine Citation:
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PMID: 22071315 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Central or neurogenic diabetes insipidus results from a deficiency in antidiuretic hormone (ADH) or arginine-vasopressin (AVP). Treatment is based on replacement therapy with the hormone analog desmopressin (d-DAVP). d-DAVP can be administered subcutaneously to infants or patients with postoperative or posttraumatic brain injury being monitored for transient diabetes insipidus. Intranasal and oral forms are also available. The recently introduced lyophilisate, which melts under the tongue, has replaced the tablet form (recently withdrawn from the market in France) and provides better bioavailability. Irrespective of the mode of administration, it is usually the patient who finds the effective minimal dose necessary for a normal life, i.e. without excessive polyuria, particularly at night. Patient education is necessary to avoid the risk of water intoxication and hyponatremia. |
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Authors:
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Philippe Chanson; Sylvie Salenave |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-7 |
Journal Detail:
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Title: Annales d'endocrinologie Volume: - ISSN: 0003-4266 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0116744 Medline TA: Ann Endocrinol (Paris) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Masson SAS. |
Affiliation:
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Service d'endocrinologie et des maladies de la reproduction, hôpitaux universitaires Paris-Sud, hôpital de Bicêtre, université Paris-Sud 11, Inserm U693, AP-HP, 78, rue du Général-Leclerc, 94275 Le Kremlin-Bicêtre, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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