Document Detail

Treatment of negative schizophrenic symptoms with trihexyphenidyl.
MedLine Citation:
PMID:  3379147     Owner:  NLM     Status:  MEDLINE    
In an effort to investigate reports of possible benefits of trihexyphenidyl on residual schizophrenic symptoms, the drug was administered to five chronic schizophrenic patients with predominantly negative symptoms. These patients were simultaneously receiving various antipsychotic agents without extrapyramidal side effects. There was a marked improvement in four of the five patients, mainly in the areas of affective flattening, anhedonia-asociality, and avolition-apathy. Three of these four patients also reported a reduction in excessive dreaming and nightmares experienced prior to the introduction of trihexyphenidyl. Common pathogenetic mechanisms for negative schizophrenic symptoms and excessive dreaming are discussed. In view of these findings, an investigation of the therapeutic benefits of anticholinergic agents in the treatment of negative schizophrenic symptoms, and the use of decreased dreaming as a possible marker of response, is warranted.
R Tandon; J F Greden; K R Silk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  8     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-27     Completed Date:  1988-07-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  212-5     Citation Subset:  IM    
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor 48109-0120.
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MeSH Terms
Middle Aged
Schizophrenia / drug therapy*
Trihexyphenidyl / adverse effects,  therapeutic use*
Reg. No./Substance:

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