Document Detail

Treatment of murine cutaneous melanoma with near infrared light.
MedLine Citation:
PMID:  11950096     Owner:  NLM     Status:  MEDLINE    
Treatment of cutaneous melanoma (M-3 and B16-F10 implanted in mice) with rapidly-scanned, tightly-focused near infrared light elicits selective destruction of tumor tissue. A single laser treatment yielded complete eradication in >90% of B16-F10 tumors with thicknesses of approximately 3 mm; amelanotic M-3 tumors proved less responsive (ca 25% clearance rate). In addition to local tumor destruction, laser treatment of B16-F10 tumors in immunocompetent mice stimulated enhanced cytokine levels (interleukin-2 and interleukin-10) within treated tumor tissues and rejection of tumor cells upon a subsequent challenge dose. Such an antitumor immune response may lead to improved outcomes at both the treatment site and at sites of distant metastasis.
C Dees; J Harkins; M G Petersen; W G Fisher; E A Wachter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  75     ISSN:  0031-8655     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-04-12     Completed Date:  2002-05-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Photongen, Inc., Knoxville, TN 37931, USA.
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MeSH Terms
Infrared Rays*
Melanoma, Experimental / immunology,  pathology,  radiotherapy*
Mice, Inbred C57BL
Mice, Nude
Skin Neoplasms / immunology,  pathology,  radiotherapy*

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