Document Detail

Treatment of multiple arteriovenous malformations in pediatric patients with hereditary hemorrhagic telangiectasia and spontaneous hemorrhage. Report of two cases.
MedLine Citation:
PMID:  18154019     Owner:  NLM     Status:  MEDLINE    
Due to inheritance of an autosomal dominant genetic mutation, patients with hereditary hemorrhagic telangiectasia (HTT) have an increased risk of harboring a cerebral arteriovenous malformation (AVM). They are also significantly more likely to have multiple AVMs. The natural history of AVMs in patients with HHT as well as their rate of hemorrhage is not clearly defined. Furthermore, spontaneous regression of such lesions has been reported. Treatment of cerebral AVMs in patients with HHT presents a particular challenge, especially with detection of incidental lesions following screening of asymptomatic patients. The management of HHT in two pediatric patients in whom hemorrhaging from a cerebral AVM occurred but who also had other lesions is presented here. Both patients were treated with stereotactic radiosurgery.
Yu-Hung Kuo; Stephen Santoreneos; Daniel Roos; Brian P Brophy
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  107     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-24     Completed Date:  2008-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  489-94     Citation Subset:  AIM; IM    
Department of Neurosurgery, Royal Adelaide Hospital, Adelaide, South Australia.
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MeSH Terms
Cerebral Angiography
Intracranial Arteriovenous Malformations / complications,  genetics,  surgery*
Intracranial Hemorrhages / complications,  genetics,  surgery*
Neurosurgical Procedures
Postoperative Care
Telangiectasia, Hereditary Hemorrhagic / complications,  genetics,  surgery*
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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