| Treatment of multidrug-resistant tuberculosis in Taiwan. | |
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MedLine Citation:
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PMID: 8980864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Eighty-seven patients with multidrug-resistant tuberculosis (MDR-TB) diagnosed between 1988 and 1990 were treated with isoniazid and at least three other effective second-line drugs based on in vitro susceptibility tests. Of these patients, 10% failed to adhere to the regimen and 43% remained sputum positive after 6 months of treatment. Only 47% showed sputum conversion within 6 months of treatment and 12% of them relapsed during the first year of follow-up. From September 1987 to July 1989, 36 patients with MDR-TB were treated with a regimen containing rifabutin, isoniazid and at least three other susceptible drugs. Only 47% achieved a sustained sputum conversion. Four died during treatment due to disease progression. From March 1992 to July 1993, 17 cases of MDR-TB were treated with an ofloxacin-containing anti-TB regimen for 12-24 months. Two failed to adhere to the regimen for more than 1 month during the first 6 months of therapy. Among the remaining 15, 26% failed to achieve sputum conversion, 73% achieved bacterial conversion, 9 within 1 month and the other 2 within 2 months. No significant adverse effect was associated with ofloxacin use. We concluded that ofloxacin is a better choice among the more toxic and less potent second-line drugs, and should be used along with other anti-TB drugs in treating patients with MDR-TB. |
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Authors:
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J Suo; M C Yu; C N Lee; C Y Chiang; T P Lin |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Chemotherapy Volume: 42 Suppl 3 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1996 |
Date Detail:
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Created Date: 1997-03-26 Completed Date: 1997-03-26 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 20-3; discussion 30-3 Citation Subset: IM |
Affiliation:
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Taiwan Provincial Chronic Disease Control Bureau, Taipei. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antitubercular Agents / therapeutic use Case-Control Studies Drug Resistance, Multiple Drug Therapy, Combination Female Humans Male Microbial Sensitivity Tests Middle Aged Mycobacterium tuberculosis / drug effects Ofloxacin / therapeutic use* Sputum / drug effects, microbiology Taiwan Treatment Outcome Tuberculosis, Multidrug-Resistant / drug therapy*, epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents; 82419-36-1/Ofloxacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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