Document Detail

Treatment of moderate to severe hypertensive patients with an orally active converting-enzyme inhibitor.
MedLine Citation:
PMID:  232914     Owner:  NLM     Status:  MEDLINE    
Seventeen hypertensive patients were treated with captopril, an orally active inhibitor of converting-enzyme. All patients showed a fall in blood pressure (BP), although in some patients only after the addition of diuretics. In 2 patients a skin rash developed. One patient developed proteinuria. A renal biopsy revealed membranous glomerulopathy. Correlations were found between pretreatment plasma renin activity (PRA) and the decrease in BP, and between pretreatment PRA and the decrease in plasma aldosterone concentration (PAC). Filtration fraction (FF) fell, indicating a decrease in renal vascular resistance. Captopril decreased the sensitivity to exogenous angiotensin I (AI), dependent on the captopril dose used. The sensitivity to exogenous bradykinin increased impressively even on the lowest dose of the drug. These observations suggest extrapulmonary conversion of AI to angiotensin II (AII).
E J Prins; A J Donker; S J Hoorntje; F H Leenen; G K van der Hem
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association     Volume:  16     ISSN:  0071-2736     ISO Abbreviation:  Proc Eur Dial Transplant Assoc     Publication Date:  1979  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  0355210     Medline TA:  Proc Eur Dial Transplant Assoc     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  603-9     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Angiotensin-Converting Enzyme Inhibitors*
Blood Pressure / drug effects
Captopril / administration & dosage*,  adverse effects,  therapeutic use
Glomerular Filtration Rate / drug effects
Hypertension / drug therapy*
Kidney / blood supply
Middle Aged
Proline / analogs & derivatives*
Renin / blood
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 147-85-3/Proline; 62571-86-2/Captopril; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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