Document Detail

Treatment of metastatic invasive moles in two husband-side sisters-in-law. Case reports and review of literature.
MedLine Citation:
PMID:  11874069     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF INVESTIGATION: The treatment of "high risk" persistent trophoblastic disease (PTD) consists of poly-chemotherapy. This policy probably will lead to overtreatment of some patients. Also, familiar molar pregnancies through the paternal line are unknown in the literature up till now. METHODS: We describe two cases of "high risk" PTD in two husband-side sisters-in-law, in which poly-chemotherapy was stopped after histology became available and showed invasive metastatic mole. CONCLUSION: It should be stressed that treatment decisions should be made based on the concept of "high" or "low" risk PTD, but if histology becomes available, chemotherapy might be less aggressive in cases of invasive mole. If invasive mole could be familiar through the paternal line remains unclear with the current knowledge of genetics in trophoblastic disease.
M A Van Eijkeren; E A Sijmons; P O Witteveen; M J Verhaar; D M Sie-Go; A P Heintz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  European journal of gynaecological oncology     Volume:  22     ISSN:  0392-2936     ISO Abbreviation:  Eur. J. Gynaecol. Oncol.     Publication Date:  2001  
Date Detail:
Created Date:  2002-03-04     Completed Date:  2002-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8100357     Medline TA:  Eur J Gynaecol Oncol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  406-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Medical Center, Utrecht, The Netherlands.
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MeSH Terms
Neoplasm Metastasis
Trophoblastic Neoplasms / drug therapy,  genetics*,  pathology
Uterine Neoplasms / drug therapy,  genetics*,  pathology

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