| Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid. | |
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MedLine Citation:
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PMID: 14766894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid. |
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Authors:
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Wolfgang A Krueger; Bernd Kottler; Bernd E Will; Alexandra Heininger; Heinz Guggenberger; Klaus E Unertl |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of clinical microbiology Volume: 42 ISSN: 0095-1137 ISO Abbreviation: J. Clin. Microbiol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-09 Completed Date: 2004-04-09 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 7505564 Medline TA: J Clin Microbiol Country: United States |
Other Details:
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Languages: eng Pagination: 929-32 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, 72076 Tübingen, Germany. wolfgang.krueger@uni-tuebingen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Accidents, Traffic Acetamides / therapeutic use* Adolescent Anti-Infective Agents / therapeutic use* Community-Acquired Infections / cerebrospinal fluid, drug therapy Female Humans Meningitis, Bacterial / cerebrospinal fluid, drug therapy* Methicillin Resistance / genetics* Oxazolidinones / therapeutic use* Staphylococcal Infections / cerebrospinal fluid, drug therapy* Staphylococcus epidermidis / drug effects, genetics*, isolation & purification |
| Chemical | |
Reg. No./Substance:
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0/Acetamides; 0/Anti-Infective Agents; 0/Oxazolidinones; 165800-03-3/linezolid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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