Document Detail

Treatment of meningitis due to methicillin-resistant Staphylococcus epidermidis with linezolid.
MedLine Citation:
PMID:  14766894     Owner:  NLM     Status:  MEDLINE    
Methicillin-resistant Staphylococcus epidermidis (MRSE) can cause nosocomial meningitis in the presence of prosthetic devices. Vancomycin is the treatment of choice, but its penetration into the cerebrospinal fluid is poor, especially in cases without severe meningeal inflammation. We successfully used linezolid to treat a case of posttraumatic MRSE meningitis with a low-level inflammatory response. Therapeutic effectiveness was documented microbiologically and by the simultaneous measurement of linezolid levels in serum and cerebrospinal fluid.
Wolfgang A Krueger; Bernd Kottler; Bernd E Will; Alexandra Heininger; Heinz Guggenberger; Klaus E Unertl
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  42     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-09     Completed Date:  2004-04-09     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-32     Citation Subset:  IM    
Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, 72076 Tübingen, Germany.
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MeSH Terms
Accidents, Traffic
Acetamides / therapeutic use*
Anti-Infective Agents / therapeutic use*
Community-Acquired Infections / cerebrospinal fluid,  drug therapy
Meningitis, Bacterial / cerebrospinal fluid,  drug therapy*
Methicillin Resistance / genetics*
Oxazolidinones / therapeutic use*
Staphylococcal Infections / cerebrospinal fluid,  drug therapy*
Staphylococcus epidermidis / drug effects,  genetics*,  isolation & purification
Reg. No./Substance:
0/Acetamides; 0/Anti-Infective Agents; 0/Oxazolidinones; 165800-03-3/linezolid

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