Document Detail


Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid.
MedLine Citation:
PMID:  10417583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Melasma is difficult to clear. Many agents have been used, such as hydroquinone, and glycolic acid and glycolic acid peels, kojic acid, a tyrosinase inhibitor in the fungus Aspergilline oryzae. OBJECTIVE: To see if the addition of 2% kojic acid in a gel containing 10% glycolic acid and 2% hydroquinone will improve melasma further. METHODS: Forty Chinese women with epidermal melasma were treated with 2% kojic acid in a gel containing 10% glycolic acid and 2% hydroquinone on one half of the face. The other half was treated with the same application but without kojic acid. The side receiving the kojic acid was randomized. Determination of efficacy was based on clinical evaluation, photographs and self-assessment questionnaires at 4 weekly intervals until the end of the study at 12 weeks. The non-parametric Wilcoxon's rank sum test was used for statistical analysis. RESULTS: All patients showed improvement in melasma on both sides of the face. The side receiving the kojic acid did better. More than half of the melasma cleared in 24/40 (60%) patients receiving kojic acid compared to 19/40 (47.5%) patients receiving the gel without kojic acid. In 2 patients, there was complete clearance of melasma, and this was on the side where kojic acid was used. Side effects include redness, stinging, and exfoliation. These were seen on both sides of the face, and they settled by the third week. CONCLUSION: The addition of kojic acid to a gel containing 10% glycolic acid and 2% hydroquinone further improves melasma.
Authors:
J T Lim
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  25     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-08-17     Completed Date:  2000-08-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  282-4     Citation Subset:  IM    
Affiliation:
National Skin Care Center, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aspergillus oryzae
Double-Blind Method
Drug Combinations
Facial Dermatoses / drug therapy*,  pathology
Female
Gels
Glycolates / therapeutic use*
Humans
Hydroquinones / therapeutic use*
Keratolytic Agents / therapeutic use*
Melanosis / drug therapy*,  pathology
Middle Aged
Mycotoxins / therapeutic use*
Pyrones / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Gels; 0/Glycolates; 0/Hydroquinones; 0/Keratolytic Agents; 0/Mycotoxins; 0/Pyrones; 123-31-9/hydroquinone; 501-30-4/kojic acid; 79-14-1/glycolic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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