Document Detail

Treatment of meconium aspiration syndrome with surfactant lavage in an experimental rabbit model.
MedLine Citation:
PMID:  10406046     Owner:  NLM     Status:  MEDLINE    
Meconium aspiration syndrome (MAS) is a frequent cause of respiratory distress in term infants. Recent reports suggested that surfactant dysfunction contributes to the pathophysiology of MAS. In the present study, we assessed the effect of three different concentrations of surfactant suspensions in the lavage fluid of a rabbit model of MAS. Young animals were given 5 mL/kg of a 20% slurry of human meconium into the endotracheal tube and were then mechanically ventilated. The animals were divided into four groups receiving lavage fluids with either saline or surfactant suspensions (2.5 mg/mL, 5 mg/mL, and 10 mg/mL). Lavage was performed an hour after meconium instillation with one of the four solutions at 10 mL/kg in three divided doses. After lavage, the total amount of meconium recovered was measured. The 10 mg/mL surfactant lavage group had the best improvement in gas exchange, whereas the saline group had no improvement. The amount of meconium recovered was the best in the 10 mg/mL surfactant group among the four groups studied. On histologic examination, alveolar inflammation was less evident in the surfactant lavage groups than in the saline lavage group. It was concluded that lavage with surfactant solution at a concentration of 10 mg/mL washed out meconium most effectively, and improved gas exchange and lung histology in the rabbit model of MAS more than saline lavage.
Y Ohama; Y Ogawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  28     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  18-23     Citation Subset:  IM    
Department of Pediatrics, Saitama Medical Center, Saitama Medical School, Japan.
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MeSH Terms
Analysis of Variance
Animals, Newborn
Bronchoalveolar Lavage
Bronchoalveolar Lavage Fluid / chemistry*
Disease Models, Animal
Infant, Newborn
Lung / drug effects,  pathology
Meconium Aspiration Syndrome / complications,  drug therapy*
Pulmonary Surfactants / administration & dosage*,  analysis
Reference Values
Respiratory Distress Syndrome, Newborn / drug therapy*,  etiology
Treatment Outcome
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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