| Treatment of male infertility due to sperm surface antibodies: IUI or IVF? | |
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MedLine Citation:
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PMID: 9221994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This prospectively designed study was aimed at comparing the results of two different treatment protocols in 29 infertile couples with proven male immunological infertility, i.e. a positive (>50%) mixed antiglobulin reaction (MAR) test (IgG and/or IgA). In the first protocol (group I, n = 14) couples were treated with ovarian stimulation/ intrauterine insemination (IUI), followed by in-vitro fertilization (IVF) if no pregnancy occurred after three IUI cycles. In the second protocol (group II, n = 15), patients were treated with IVF as a first choice procedure. The decision to follow protocol 1 or 2 was made by the couples after information about financial costs and expected success rates (according to the literature) for both treatment options. In group I, nine patients (64.3%) conceived after a maximum of three IUI cycles whereas seven patients (46.6%) of group II became pregnant during the first IVF cycle. The take-home baby rate per started IUI or IVF cycle was 27.3% (9/33) and 44.4% (16/36) respectively with a take-home baby rate of 64.3% after three IUI cycles and 93.3% after three IVF attempts. To conclude, both IUI and IVF yielded unexpectedly high pregnancy rates in this selected group of patients with long-standing infertility due to sperm surface (predominantly IgG) antibodies. Since cost benefit analysis comparing superovulation IUI with IVF may favour a course of four IUI cycles, we advocate superovulation IUI as the first line therapy in male immunological infertility. |
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Authors:
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W Ombelet; H Vandeput; M Janssen; A Cox; C Vossen; H Pollet; O Steeno; E Bosmans |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 12 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-09-24 Completed Date: 1997-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1165-70 Citation Subset: IM |
Affiliation:
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Genk Institute for Fertility Technology, St Jansziekenhuis, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autoantibodies / metabolism* Clinical Protocols Coombs' Test Female Fertilization in Vitro* Humans Infertility, Male / diagnosis, immunology*, therapy* Insemination, Artificial, Homologous* Male Ovulation Induction Pregnancy Prospective Studies Spermatozoa / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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