| Treatment of lipid disorders in obesity. | |
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MedLine Citation:
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PMID: 21878051 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Obesity is the most common cause of secondary hyperlipidemia. Atherogenic dyslipidemia refers to elevated triglycerides, low HDL-cholesterol and small dense LDL associated with visceral obesity and metabolic syndrome. Obesity may also be associated with isolated low HDL-cholesterol or high triglycerides and postprandial hyperlipidemia. While some obese patients have high LDL cholesterol concentrations, obesity has a more pronounced effect on other atherogenic lipids and lipoproteins. Obesity may aggravate familial lipid disorders. Lipid disorders in obesity are responsive to weight loss, pharmacotherapy and weight loss surgery. Statins are the lipid-lowering drug of choice, together with lifestyle change. Hard clinical end point data to support combinations of statins with other drugs is lacking. After weight loss surgery, the absolute risk of cardiovascular disease should be reassessed, but tools to facilitate risk assessment need to be developed. |
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Authors:
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Serena Tonstad; Jean-Pierre Després |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 9 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 1069-80 Citation Subset: IM |
Affiliation:
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Department of Health Promotion and Education, School of Public Health, 24951 North Circle Drive, Loma Linda, CA 92354, USA. stonstad@llu.edu. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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