Document Detail

Treatment of left main and multivessel disease in the drug-eluting stent era.
MedLine Citation:
PMID:  19898278     Owner:  NLM     Status:  MEDLINE    
For decades, the established standard of care for left main and multivessel coronary artery disease has been coronary artery bypass surgery because a significant survival advantage was found in patients revascularized with surgery compared with medical management. Although visions of less invasive strategies to manage this disease arose with the development of percutaneous coronary interventions, surgery proved to provide higher survival rates compared with balloon angioplasty and improved durability, with fewer required repeat revascularizations, compared with use of bare-metal stents. Drug-eluting stents revived hopes of an alternative treatment modality after trials demonstrated their safety and efficacy in other types of high-risk patients. Their wide-spread on- and off-label use led to several nonrandomized studies and, more recently, to randomized clinical trials comparing drug-eluting stents and bypass surgery.
Vivian G Ng; Alexandra J Lansky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reviews in cardiovascular medicine     Volume:  10 Suppl 2     ISSN:  1530-6550     ISO Abbreviation:  Rev Cardiovasc Med     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100960007     Medline TA:  Rev Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S24-33     Citation Subset:  IM    
Columbia University Medical Center and The Cardiovascular Research Foundation, New York, NY, USA.
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MeSH Terms
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*,  mortality
Coronary Artery Bypass
Coronary Artery Disease / diagnosis,  mortality,  therapy*
Drug-Eluting Stents*
Evidence-Based Medicine
Patient Selection
Prosthesis Design
Risk Assessment
Severity of Illness Index
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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