Document Detail

Treatment of laryngopharyngeal reflux improves asthma symptoms in asthmatics.
MedLine Citation:
PMID:  16939995     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Laryngopharyngeal reflux (LPR) is defined as the movement of gastric content toward laryngopharynx and is a common occurrence in patients with asthma. This study aimed (1) to determine the incidence of LPR in patients with asthma by assessment of symptom scores and indirect laryngoscopy and (2) to determine the effect of LPR treatment on asthma symptom scores.
METHODS: A total of 28 patients with mild to moderate asthma (24 women, 4 men, mean age 46 +/- 6 years) were included in the study, and after all patients completed LPR and asthma symptom questionnaires, indirect videolaryngoscopy was performed. In patients with LPR, daily treatment with 40 mg pantoprazole was administered for 3 months. Symptom score assessment and indirect videolaryngoscopic examination were repeated at the end of treatment.
RESULTS: A diagnosis of LPR was made in 21 of 28 patients (75%) by indirect laryngoscopy. A statistically significant improvement was observed in asthma and LPR symptoms in patients with LPR after the treatment (p = 0.001 and p < 0.001, respectively).
CONCLUSIONS: LPR is a frequent condition in asthma patients. When the LPR symptom questionnaire and indirect laryngoscopy findings are suggestive of LPR, treatment with a proton pump inhibitor provides improvement in both asthma and LPR symptoms.
Emel Eryuksel; Muzeyyen Dogan; Pejman Golabi; M Ali Sehitoglu; Turgay Celikel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  43     ISSN:  0277-0903     ISO Abbreviation:  J Asthma     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2006-10-17     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-42     Citation Subset:  IM    
Department of Pulmonology and Critical Care, Marmara University Hospital, Istanbul, Turkey.
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MeSH Terms
Anti-Ulcer Agents / therapeutic use*
Asthma / diagnosis,  drug therapy*,  epidemiology,  etiology
Benzimidazoles / therapeutic use*
Combined Modality Therapy
Cross-Sectional Studies
Food Habits
Gastroesophageal Reflux / complications,  diagnosis,  drug therapy*,  epidemiology
Life Style
Middle Aged
Omeprazole / analogs & derivatives*,  therapeutic use
Statistics as Topic
Sulfoxides / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Benzimidazoles; 0/Sulfoxides; 73590-58-6/Omeprazole; D8TST4O562/pantoprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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