Document Detail

Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid.
MedLine Citation:
PMID:  22513879     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study aimed to find a simple, cost-effective, and time-efficient method for the preparation of platelet-rich plasma (PRP), so the acquired benefits will be readily available for multiple procedures in smaller outpatient clinics and to explore the safety and efficacy of the application of PRP in the treatment of degenerative lesions of articular cartilage of the knee.
DESIGN: The study was designed as a prospective, cohort study with a control group. A total of 120 patients with Grade 1, 2, or 3 osteoarthritis according to the Kellgren and Lawrence grading scale were enrolled in the study. One group of patients was treated using three intra-articular applications of PRP, and the second group of patients was given three injections of hyaluronic acid. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index and the 11-point pain intensity Numeric Rating Scale.
RESULTS: On average, a 4.5-fold increase in platelet concentration was obtained in the PRP group. No severe adverse events were observed. Statistically significantly better results in the Western Ontario and McMaster Universities Osteoarthritis Index and Numeric Rating Scale scores were recorded in a group of patients who received PRP injections after a 3- and 6-mo follow-up.
CONCLUSIONS: Our preliminary findings support the application of autologous PRP as an effective and safe method in the treatment of the initial stages of knee osteoarthritis. Further studies are needed to confirm these results and to investigate the persistence of the beneficial effects observed.
Tímea Spaková; Ján Rosocha; Marek Lacko; Denisa Harvanová; Ahmed Gharaibeh
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  91     ISSN:  1537-7385     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-19     Completed Date:  2012-06-19     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Transfusion, Autologous
Cohort Studies
Hyaluronic Acid / therapeutic use*
Injections, Intra-Articular
Middle Aged
Osteoarthritis, Knee / drug therapy*
Platelet-Rich Plasma*
Treatment Outcome
Viscosupplements / therapeutic use*
Young Adult
Reg. No./Substance:
0/Viscosupplements; 9004-61-9/Hyaluronic Acid
Comment In:
Am J Phys Med Rehabil. 2014 Jan;93(1):95   [PMID:  24501778 ]
Am J Phys Med Rehabil. 2014 Jan;93(1):95   [PMID:  23370592 ]
Am J Phys Med Rehabil. 2014 Jan;93(1):95   [PMID:  23370585 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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