Document Detail


Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid.
MedLine Citation:
PMID:  22513879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study aimed to find a simple, cost-effective, and time-efficient method for the preparation of platelet-rich plasma (PRP), so the acquired benefits will be readily available for multiple procedures in smaller outpatient clinics and to explore the safety and efficacy of the application of PRP in the treatment of degenerative lesions of articular cartilage of the knee.
DESIGN: The study was designed as a prospective, cohort study with a control group. A total of 120 patients with Grade 1, 2, or 3 osteoarthritis according to the Kellgren and Lawrence grading scale were enrolled in the study. One group of patients was treated using three intra-articular applications of PRP, and the second group of patients was given three injections of hyaluronic acid. Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index and the 11-point pain intensity Numeric Rating Scale.
RESULTS: On average, a 4.5-fold increase in platelet concentration was obtained in the PRP group. No severe adverse events were observed. Statistically significantly better results in the Western Ontario and McMaster Universities Osteoarthritis Index and Numeric Rating Scale scores were recorded in a group of patients who received PRP injections after a 3- and 6-mo follow-up.
CONCLUSIONS: Our preliminary findings support the application of autologous PRP as an effective and safe method in the treatment of the initial stages of knee osteoarthritis. Further studies are needed to confirm these results and to investigate the persistence of the beneficial effects observed.
Authors:
Tímea Spaková; Ján Rosocha; Marek Lacko; Denisa Harvanová; Ahmed Gharaibeh
Related Documents :
22525979 - Alopecia associated with strontium ranelate use in a 62-year-old woman.
22715499 - Effectiveness of the reverse camber shoe in postoperative hallux valgus surgery.
9065919 - Specific power calculations for magnetic resonance imaging (mri) in monitoring active r...
22616799 - The relationships between preoperative sexual desire and quality of life following radi...
22569619 - Open versus closed enteral nutrition systems for critically ill adults: is there a diff...
7741169 - Long-term efficacy of primaquine in the treatment of vivax malaria in nonimmune travelers.
16954919 - The effect of skull volume and density on differentiating gray and white matter on rout...
24016669 - Regeneration of chronic tympanic membrane perforation using 3d collagen with topical um...
14685109 - Venous claudication in iliofemoral thrombosis: long-term effects on venous hemodynamics...
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  91     ISSN:  1537-7385     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-19     Completed Date:  2012-06-19     Revised Date:  2014-02-06    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Transfusion, Autologous
Cohort Studies
Female
Humans
Hyaluronic Acid / therapeutic use*
Injections, Intra-Articular
Male
Middle Aged
Osteoarthritis, Knee / drug therapy*
Platelet-Rich Plasma*
Treatment Outcome
Viscosupplements / therapeutic use*
Young Adult
Chemical
Reg. No./Substance:
0/Viscosupplements; 9004-61-9/Hyaluronic Acid
Comments/Corrections
Comment In:
Am J Phys Med Rehabil. 2014 Jan;93(1):95   [PMID:  24501778 ]
Am J Phys Med Rehabil. 2014 Jan;93(1):95   [PMID:  23370592 ]
Am J Phys Med Rehabil. 2014 Jan;93(1):95   [PMID:  23370585 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predictors of discharge to acute care after inpatient rehabilitation in severely affected stroke pat...
Next Document:  A mannitol based phase selective supergelator offers a simple, viable and greener method to combat m...