| Treatment of ischaemic jejunum with topical and intraluminal Carolina Rinse. | |
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MedLine Citation:
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PMID: 12358049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carolina Rinse Solution (CRS) was applied topically and intraluminally to ischaemic (Group 1; n = 5) and distended equine jejunum (Group 2; n = 5). Mesenteric blood flow, ORC (osmotic reflection coefficient), wet weight to dry weight ratios (WW/DW), serosal thickness, and neutrophil accumulation in the serosa were measured. After 60 min ischaemia followed by reperfusion (Group 1), mesenteric blood flow remained greater than baseline values. The mean ORC was similar to that previously reported in normal bowel or ischaemic intestine treated with CRS by arterial perfusion. The ORC after distention and decompression (Group 2) increased and was similar to that previously reported in a comparable untreated experimental model. The WW/DW after both ischaemia and distention increased compared to specimens collected from noninstrumented jejunum proximal to the experimental segments in the same horses. There was no difference in neutrophil numbers in the serosa of either ischaemic or distended intestine compared to the noninstrumented proximal jejunum. CRS-treated ischaemic intestine maintained microvascular permeability similar to that reported for normal intestine whereas treated distended intestine did not. Combined topical and intraluminal application of CRS to ischaemic intestine may reduce complications due to acute inflammation during reperfusion. |
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Authors:
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B L Young; N A White; L L Donaldson; R M Dabareiner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Equine veterinary journal Volume: 34 ISSN: 0425-1644 ISO Abbreviation: Equine Vet. J. Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-10-02 Completed Date: 2003-01-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: England |
Other Details:
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Languages: eng Pagination: 469-74 Citation Subset: IM |
Affiliation:
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Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, VPI & SU, Leesburg, Virginia 20177, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Animals Blood Flow Velocity / veterinary Capillary Permeability Female Horse Diseases / drug therapy* Horses Ischemia / drug therapy, veterinary* Jejunum / blood supply* Leukocyte Count / veterinary Male Mesenteric Arteries / physiopathology Mesenteric Veins / physiopathology Neutrophils Reperfusion / veterinary Solutions / administration & dosage, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Carolina rinse solution; 0/Solutions |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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