Document Detail

Treatment of ischaemic digital ulcers and prevention of gangrene with intravenous iloprost in systemic sclerosis.
MedLine Citation:
PMID:  8800308     Owner:  NLM     Status:  MEDLINE    
Twelve patients with systemic sclerosis were treated with intravenous infusions of the prostacyclin-stable analogue iloprost 0.5-2.0 ng/kg/min for 6 h from 8 to 13 days. Imminent gangrene was stopped in 2 patients and followed by healing. In 4 of 6 patients iloprost led to complete healing of ischaemic ulcers and in the remaining 2 patients to partial healing. One patient with severe Raynaud's phenomenon discontinued the study after 3 days due to severe headache. The 2 remaining patients with Raynaud's phenomenon as an indication improved, while no improvement was recorded in a patient with vasculitis of the lower leg. Side-effects such as headache, nausea and flushing were the reason that only 5 patients reached the maximum infusion rate. No statistical differences were recorded in digital bloodflow before and after the study or in plasma endothelin in the 9 patients investigated. Three of the 6 patients with healing ulcers, however, showed a pronounced decrease in plasma endothelin. Iloprost appears useful as a treatment of imminent gangrene and ischaemic ulcers in systemic sclerosis. This reparatory capacity could also be of a more general importance in therapy of this disease.
H Zachariae; L Halkier-Sørensen; P Bjerring; L Heickendorff
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  76     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-04-08     Completed Date:  1997-04-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  236-8     Citation Subset:  IM    
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
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MeSH Terms
Endothelins / blood
Fingers / blood supply*
Gangrene / etiology,  prevention & control
Iloprost / administration & dosage*,  adverse effects
Infusions, Intravenous
Ischemia / drug therapy*,  etiology
Middle Aged
Raynaud Disease / drug therapy,  etiology
Scleroderma, Systemic / blood,  complications*
Ulcer / drug therapy,  etiology
Vasodilator Agents / adverse effects*
Reg. No./Substance:
0/Endothelins; 0/Vasodilator Agents; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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