Document Detail


Treatment of intestinal graft-versus-host disease using betamethasone enemas.
MedLine Citation:
PMID:  11685119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intestinal graft-versus-host disease (GVHD) can readily easily induce generalized metabolic disturbance that influences morbidity and mortality after allogeneic bone marrow transplantation. Although adding a new drug or increasing the doses of immunosuppressive agents will probably be effective for controlling intestinal GVHD, the systemic side effects of such therapy cannot be ignored. In this study, we used betamethasone retention enemas as a local treatment for eight patients with refractory and/or severe intestinal GVHD. Six of the eight patients showed improvement of diarrhea and/or abdominal pain, with a reduction in the stage of GVHD. When treatment with betamethasone enemas was continued for 10 to 27 days in the 6 responding patients, no severe toxicity was observed. One patient failed to respond to treatment and another could not tolerate the enemas. Despite some uncertainty regarding the indications and duration of treatment, betamethasone enemas seem to be a potential alternative method for the management of intestinal GVHD.
Authors:
H Wada; A Mori; M Okada; H Takatsuka; A Tamura; Y Seto; N Iwata; Y Fujimori; T Okamoto; Y Takemoto; E Kakishita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  72     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1451-3     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya City, Hyogo 663-8501, Japan.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Anti-Inflammatory Agents / administration & dosage*
Betamethasone / administration & dosage*
Bone Marrow Transplantation / adverse effects*
CD4 Lymphocyte Count
Enema
Female
Glucocorticoids
Graft vs Host Disease / drug therapy*
Humans
Intestinal Diseases / drug therapy*
Male
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Glucocorticoids; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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