Document Detail

Treatment of inhalant dependence with lamotrigine.
MedLine Citation:
PMID:  17254687     Owner:  NLM     Status:  MEDLINE    
The sites of action of inhalant drugs are not completely known but recent studies suggest that ion channels that regulate neuronal excitability may be particularly sensitive. Lamotrigine, a newer anticonvulsant, has a modulating effect on excitatory amino acid-glutamate. We describe the use of lamotrigine in the treatment of a patient with inhalant dependence. A 21-year-old male with no history of other substance problems complained of problems with exacerbating use of inhalants for 4 years. He received a course of individual and behavior psychotherapy for 2 months. However, the psychotherapy was not effective. He then was treated with lamotrigine 100 mg per day. He has been on the dose of this medication for more than 6 months and stopped the use of inhalants. Experience with our patient suggests that lamotrigine might be effective in treating inhalant dependence. Further controlled studies are required to confirm its efficacy in patients of this type.
Yu-Chih Shen
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-12-29
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  31     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-30     Completed Date:  2007-06-26     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  769-71     Citation Subset:  IM    
Department of Psychiatry, Tzu-Chi General Hospital, Hualien City, Taiwan, ROC.
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MeSH Terms
Anticonvulsants / therapeutic use
Street Drugs / adverse effects
Substance-Related Disorders / drug therapy*,  etiology
Triazines / therapeutic use*
Reg. No./Substance:
0/Anticonvulsants; 0/Street Drugs; 0/Triazines; U3H27498KS/lamotrigine

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