| Treatment of infrabony defects with or without enamel matrix proteins: a 24-month follow-up randomized pilot study. | |
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MedLine Citation:
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PMID: 20165744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate a comparison of open-flap debridement (OFD) with or without the use of enamel matrix proteins (EMP) for the treatment of infrabony defects. METHOD AND MATERIALS: Ten volunteers (38 infrabony defects) were randomized to receive OFD+EMP (test site) and OFD (control site). Clinical outcomes included mean changes in Plaque Index, Gingival Index, probing pocket depth (PPD), relative attachment level (RAL), gingival recession, width of keratinized tissue, and dental mobility at baseline and at 24 months. RESULTS: A significant reduction of 4.21+/-0.97 mm was observed in PPD for the OFD+EMP group (from 6.30+/-0.99 mm to 2.09+/-0.97 mm) and of 3.28+/-1.23 mm for the OFD group (from 6.13+/-0.88 mm to 2.85+/-1.42 mm) (P<.001). The reduction in PPD was statistically significantly greater for OFD+EMP compared to OFD (P=.03). The mean RAL decreased from 13.26+/-1.88 mm to 7.57+/-2.05 mm for the OFD+EMP group (a gain of 5.69+/-1.96 mm) and from 13.37+/-1.71 mm to 8.13+/-1.34 mm (P<.001) for the OFD group (a gain of 5.24+/-1.55 mm). Gingival recession was higher in the OFD+EMP group than in the OFD group. The mean keratinized tissue significantly decreased from 4.41+/-1.39 mm to 3.63+/-1.54 mm for OFD flap group (P<.01). CONCLUSION: Both treatment modalities were efficient in improving RAL and PPD. Within groups, there was a significant reduction in keratinized tissue for OFD and a significant postoperative recession for the OFD + EMP group. Infrabony defects treated with OFD + EMP showed significantly more PPD reduction when compared to OFD. |
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Authors:
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Daniella Chambrone; Ivan Munhoz Pasin; Leandro Chambrone; Claudio Mendes Pannuti; Marina Clemente Conde; Luiz A Lima |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Quintessence international (Berlin, Germany : 1985) Volume: 41 ISSN: 1936-7163 ISO Abbreviation: Quintessence Int Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-18 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0342677 Medline TA: Quintessence Int Country: Germany |
Other Details:
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Languages: eng Pagination: 125-34 Citation Subset: D |
Affiliation:
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Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil. chambrone@usp.br |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alveolar Bone Loss / surgery, therapy* Bone Regeneration Chronic Periodontitis / surgery, therapy* Dental Enamel Proteins / therapeutic use* Female Gingival Recession / etiology, surgery, therapy Humans Male Matched-Pair Analysis Middle Aged Periodontal Attachment Loss / surgery, therapy Periodontal Debridement* / adverse effects Periodontal Pocket / surgery, therapy Pilot Projects Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dental Enamel Proteins; 0/enamel matrix proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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