Document Detail

Treatment of infrabony defects with or without enamel matrix proteins: a 24-month follow-up randomized pilot study.
MedLine Citation:
PMID:  20165744     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate a comparison of open-flap debridement (OFD) with or without the use of enamel matrix proteins (EMP) for the treatment of infrabony defects.
METHOD AND MATERIALS: Ten volunteers (38 infrabony defects) were randomized to receive OFD+EMP (test site) and OFD (control site). Clinical outcomes included mean changes in Plaque Index, Gingival Index, probing pocket depth (PPD), relative attachment level (RAL), gingival recession, width of keratinized tissue, and dental mobility at baseline and at 24 months.
RESULTS: A significant reduction of 4.21+/-0.97 mm was observed in PPD for the OFD+EMP group (from 6.30+/-0.99 mm to 2.09+/-0.97 mm) and of 3.28+/-1.23 mm for the OFD group (from 6.13+/-0.88 mm to 2.85+/-1.42 mm) (P<.001). The reduction in PPD was statistically significantly greater for OFD+EMP compared to OFD (P=.03). The mean RAL decreased from 13.26+/-1.88 mm to 7.57+/-2.05 mm for the OFD+EMP group (a gain of 5.69+/-1.96 mm) and from 13.37+/-1.71 mm to 8.13+/-1.34 mm (P<.001) for the OFD group (a gain of 5.24+/-1.55 mm). Gingival recession was higher in the OFD+EMP group than in the OFD group. The mean keratinized tissue significantly decreased from 4.41+/-1.39 mm to 3.63+/-1.54 mm for OFD flap group (P<.01).
CONCLUSION: Both treatment modalities were efficient in improving RAL and PPD. Within groups, there was a significant reduction in keratinized tissue for OFD and a significant postoperative recession for the OFD + EMP group. Infrabony defects treated with OFD + EMP showed significantly more PPD reduction when compared to OFD.
Daniella Chambrone; Ivan Munhoz Pasin; Leandro Chambrone; Claudio Mendes Pannuti; Marina Clemente Conde; Luiz A Lima
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Quintessence international (Berlin, Germany : 1985)     Volume:  41     ISSN:  1936-7163     ISO Abbreviation:  Quintessence Int     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-18     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0342677     Medline TA:  Quintessence Int     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  125-34     Citation Subset:  D    
Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
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MeSH Terms
Alveolar Bone Loss / surgery,  therapy*
Bone Regeneration
Chronic Periodontitis / surgery,  therapy*
Dental Enamel Proteins / therapeutic use*
Gingival Recession / etiology,  surgery,  therapy
Matched-Pair Analysis
Middle Aged
Periodontal Attachment Loss / surgery,  therapy
Periodontal Debridement* / adverse effects
Periodontal Pocket / surgery,  therapy
Pilot Projects
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Dental Enamel Proteins; 0/enamel matrix proteins

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