Document Detail

Treatment of infants with neurogenic bladder dysfunction using anticholinergic drugs and intermittent catheterisation.
MedLine Citation:
PMID:  2249125     Owner:  NLM     Status:  MEDLINE    
The use of anticholinergic drugs in infants with neurogenic dysfunction has not been well documented. In this study, 35 neonates at risk of upper urinary tract damage from neurogenic dysfunction were treated from infancy with anticholinergics, in combination with clean intermittent catheterisation. None of the patients showed upper urinary tract deterioration with follow-up ranging from 6 to 72 months, although 2 required vesicostomy--1 due to difficulty with catheterisation and 1 due to possible anticholinergic side effects. Only 2 (6%) have had clinical pyelonephritis. Twenty-five (76%) are virtually dry between catheterisation. We conclude that anticholinergics are safe and effective, even in the neonatal period, when used in combination with clean intermittent catheterisation for the treatment of neonates with neurogenic bladder dysfunction.
L S Baskin; B A Kogan; F Benard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of urology     Volume:  66     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-01-11     Completed Date:  1991-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  532-4     Citation Subset:  IM    
Department of Urology, University of California School of Medicine, San Francisco.
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MeSH Terms
Combined Modality Therapy
Infant, Newborn
Mandelic Acids / therapeutic use*
Meningomyelocele / complications
Parasympatholytics / therapeutic use*
Urinary Bladder, Neurogenic / etiology,  therapy*
Urinary Catheterization*
Reg. No./Substance:
0/Mandelic Acids; 0/Parasympatholytics; 5633-20-5/oxybutynin

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