Document Detail


Treatment of an infant with severe acute refractory immune thrombocytopenic purpura using combination therapy including rituximab.
MedLine Citation:
PMID:  19301247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some infants with acute immune thrombocytopenic purpura (ITP) do not respond to first-line therapy, and currently there is no consensus on therapy for these refractory cases. We describe a 12-week-old infant with acute ITP who was unresponsive to intravenous immunoglobulin and corticosteroid, and developed gastrointestinal bleeding. Several combination therapies were unsuccessful. After four doses of rituximab followed by intravenous immunoglobulin and corticosteroid, his platelet counts gradually increased. Combined therapy which includes rituximab may be a promising treatment for severe acute refractory ITP.
Authors:
Kotoe Iesato; Naoki Hatakeyama; Masaki Yamamoto; Tsukasa Hori; Natsuko Inazawa; Hiroyuki Tsutsumi; Nobuhiro Suzuki
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric blood & cancer     Volume:  53     ISSN:  1545-5017     ISO Abbreviation:  Pediatr Blood Cancer     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101186624     Medline TA:  Pediatr Blood Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-5     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Affiliation:
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents / administration & dosage
Antibodies, Monoclonal / administration & dosage*
Drug Therapy, Combination
Humans
Immunoglobulins, Intravenous / administration & dosage
Immunologic Factors / administration & dosage*
Infant
Male
Prednisone / administration & dosage
Purpura, Thrombocytopenic, Idiopathic / drug therapy*,  physiopathology
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Antibodies, Monoclonal; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors; 0/rituximab; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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