Document Detail

Treatment of idiopathic pulmonary fibrosis: is there anything new?
MedLine Citation:
PMID:  15955138     Owner:  NLM     Status:  MEDLINE    
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic fibrosing interstitial pneumonia of unknown aetiology and is associated with the histological picture of usual interstitial pneumonia. Treatment in most cases is unsatisfactory and the prognosis remains poor. There is insufficient evidence to suggest that any treatment, apart from lung transplantation, improves survival or halts disease progression for IPF patients. Data on treatment response are limited by the paucity of clinical trails, the lack of homogenous clinical features, the small number of patients, and the absence of histological and radiological documentation in many cases. Anti-inflammatory medications such as corticosteroids, azathioprine and cyclophosphamide remain the commonly used medications. More recently, it has been proposed that IPF is a primary fibrotic disease rather than an inflammatory condition. Antifibrotic agents such as colchicine, pirfenidone and interferon-gamma (IFN-gamma) have been tried. However, a recent placebo-controlled trial has failed to demonstrate a significant effect of IFN-gamma on disease progression, lung function or quality of life in IPF patients, though a clinically significant survival benefit of the drug could not be ruled out.
Muntasir M Abdelaziz; Yaseen S Samman; Siraj O Wali; Mahir M A Hamad
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Respirology (Carlton, Vic.)     Volume:  10     ISSN:  1323-7799     ISO Abbreviation:  Respirology     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-15     Completed Date:  2005-10-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9616368     Medline TA:  Respirology     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
Department of Respiratory Medicine, King Khalid National Guard Hospital, Jeddah, Saudi Arabia.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use*
Lung Transplantation
Pulmonary Fibrosis / drug therapy*,  surgery
Treatment Outcome
Reg. No./Substance:
0/Anti-Inflammatory Agents

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