Document Detail

Treatment of hypoxemia during xylazine-tiletamine-zolazepam immobilization of wapiti.
MedLine Citation:
PMID:  11708204     Owner:  NLM     Status:  MEDLINE    
Hypoxemia is a commonly observed complication during the chemical immobilization of wild ruminants. If severe and left untreated, it can predispose animals to arrhythmias, organ failure, and capture myopathy. The following prospective study was designed to measure the degree of hypoxemia in wapiti that were immobilized with a combination of xylazine and tiletamine-zolazepam and to assess the response to nasal oxygen therapy. Pulse oximetry and arterial blood gas analysis were used to assess the degree of hypoxemia prior to nasal insufflation of oxygen and to demonstrate any beneficial effects of this intervention. All wapiti exhibited mild to marked hypoxemia (PaO2 = 43 +/- 11.8 mmHg) prior to treatment and showed marked improvement after 5 minutes of nasal insufflation of oxygen at 10 L/min (PaO2 = 207 +/- 60 mmHg). This inexpensive, noninvasive technique has great benefit in treating clinical hypoxemia under field conditions, and we recommend that nasal insufflation of oxygen be implemented during xylazine-tiletamine-zolazepam-induced immobilization of wapiti and other wild ruminants.
M R Read; N A Caulkett; A Symington; T K Shury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian veterinary journal. La revue vétérinaire canadienne     Volume:  42     ISSN:  0008-5286     ISO Abbreviation:  Can. Vet. J.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-15     Completed Date:  2002-03-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0004653     Medline TA:  Can Vet J     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  861-4     Citation Subset:  IM    
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4.
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MeSH Terms
Adrenergic alpha-Agonists / adverse effects
Anesthetics, Dissociative / adverse effects
Animals, Wild
Anoxia / chemically induced,  drug therapy,  veterinary*
Anti-Anxiety Agents / adverse effects
Blood Gas Analysis / veterinary
Drug Combinations
Heart Rate / drug effects
Immobilization* / adverse effects
Oxygen / administration & dosage*,  blood
Prospective Studies
Respiration / drug effects
Tiletamine / adverse effects
Xylazine / adverse effects
Zolazepam / adverse effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Anesthetics, Dissociative; 0/Anti-Anxiety Agents; 0/Drug Combinations; 12794-10-4/Benzodiazepines; 14176-49-9/Tiletamine; 31352-82-6/Zolazepam; 7361-61-7/Xylazine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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