Document Detail

Treatment of hypertensive complications in pregnancy.
MedLine Citation:
PMID:  15777230     Owner:  NLM     Status:  MEDLINE    
Hypertension is the most common medical disorder during pregnancy. Approximately 70 percent of women diagnosed with hypertension during pregnancy will have gestational hypertension-preeclampsia. The term gestational hypertension-preeclampsia is used to describe a wide spectrum of patients who may have only mild elevation in blood pressure to those with severe hypertension with various organ dysfunctions (acute gestational hypertension, preeclampsia, eclampsia, and the syndrome of hemolysis, elevated liver enzymes, and low platelets (HELLP syndrome). The exact incidence of gestational hypertension-preeclampsia in the United States is unknown. Estimates range from 6% to 8% of all pregnancies. The treatment of hypertensive disorders in pregnancy requires careful assessment of the maternal and fetal conditions. Therapeutic decisions must take into account fetal age, maternal symptoms, tests of fetal well-being, as well as maternal status, in order to ensure the best overall outcome. Treatment of mild gestational hypertension with antihypertensive medications has not been shown to improve outcome, however, in cases of severe disease treatment has been shown to be beneficial. The purpose of this review is to discuss the different treatment modalities used in the hypertensive disorders of pregnancy. Management strategies will not be discussed.
K H Coppage; B M Sibai
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current pharmaceutical design     Volume:  11     ISSN:  1381-6128     ISO Abbreviation:  Curr. Pharm. Des.     Publication Date:  2005  
Date Detail:
Created Date:  2005-03-21     Completed Date:  2005-04-06     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  9602487     Medline TA:  Curr Pharm Des     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  749-57     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University of Cincinnati, 231 Albert Sabin Way, M/L 0526, Cincinnati, OH 45267, USA.
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MeSH Terms
Antihypertensive Agents / pharmacokinetics,  therapeutic use*
Contraceptive Agents, Female / adverse effects
Fetus / physiology
Hypertension / drug therapy*,  physiopathology
Hypertensive Encephalopathy / physiopathology
Infant, Newborn
Pregnancy Complications, Cardiovascular / drug therapy*,  etiology,  physiopathology
Reg. No./Substance:
0/Antihypertensive Agents; 0/Contraceptive Agents, Female

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