Document Detail

Treatment of hypertension with thiazides: benefit or damage-effect of low- and high-dose thiazide diuretics on arterial elasticity and metabolic parameters in hypertensive patients with and without glucose intolerance.
MedLine Citation:
PMID:  17684458     Owner:  NLM     Status:  MEDLINE    
Thiazide diuretics may cause multiple metabolic abnormalities. The authors investigated the effects of varying doses of hydrochlorothiazide (HCTZ) on arterial elasticity and metabolic parameters in patients with hypertension (HTN), HTN and impaired fasting glucose (HTN+IFG), and HTN and type 2 diabetes mellitus (HTN+DM). The patients received low and high doses of HCTZ. Systolic and diastolic blood pressures declined significantly during the first 3 months in all patients, but no additional decrease was seen following the increase in HCTZ dose. In HTN, large artery elasticity index and small artery elasticity increased during the study. In HTN+IFG, large artery elasticity index increased without improvement in small artery elasticity index. In HTN+DM, both large artery elasticity index and small artery elasticity index did not improve during follow-up. Low-dose HCTZ improves arterial elasticity in hypertensive patients, but this effect is diminished with concomitant DM or IFG. The HCTZ dose increase worsened parameters of glucose metabolism and did not further decrease blood pressure or improve arterial elasticity.
Marina Shargorodsky; Mona Boaz; Ina Davidovitz; Jack Asherov; Dov Gavish; Reuven Zimlichman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the cardiometabolic syndrome     Volume:  2     ISSN:  1559-4564     ISO Abbreviation:  -     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-08     Completed Date:  2007-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101284690     Medline TA:  J Cardiometab Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-23     Citation Subset:  IM    
Department of Endocrinology, Wolfson Medical Center, Holon and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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MeSH Terms
Arteries / drug effects*
Blood Pressure / drug effects
Diabetes Mellitus, Type 2 / complications
Diuretics / administration & dosage*,  adverse effects
Elasticity / drug effects
Glucose Intolerance / complications*
Hydrochlorothiazide / administration & dosage,  adverse effects
Hypertension / drug therapy*
Middle Aged
Thiazides / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Diuretics; 0/Thiazides; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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