Document Detail

Treatment of hypertension in hemodialysis patients with nifedipine.
MedLine Citation:
PMID:  6345369     Owner:  NLM     Status:  MEDLINE    
The hemodynamic effects of nifedipine were studied in nine patients with acute or chronic renal failure undergoing hemodialysis. Arterial blood pressure was lowered within 15 minutes of oral administration of nifedipine 10 mg. Mean arterial pressure and total systemic peripheral resistance were significantly decreased, whereas cardiac index and heart rate revealed slight but statistically insignificant changes. Changes in pulmonary artery diastolic pressure and mean right atrial pressure which were closely related to cardiac preload were not significant. However, the antihypertensive effect was enhanced in patients with lower pretreatment preload. Results show that oral nifedipine is effective in rapidly reducing blood pressure during or following hemodialysis.
K Kubo; K Shiraishi; H Muto; T Suzuki; N Sugino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  5     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1983 Jul-Aug
Date Detail:
Created Date:  1983-08-26     Completed Date:  1983-08-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  II109-12     Citation Subset:  IM    
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MeSH Terms
Antihypertensive Agents / therapeutic use
Hemodynamics / drug effects
Hypertension / complications,  drug therapy*
Kidney Failure, Chronic / complications,  therapy*
Kidney Transplantation
Nifedipine / therapeutic use*
Pyridines / therapeutic use*
Renal Dialysis*
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Pyridines; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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