Document Detail


Treatment of hypertension in the elderly with a new calcium channel blocking drug, nitrendipine.
MedLine Citation:
PMID:  2642658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: Treatment of hypertension in the elderly decreases cardiovascular morbidity and mortality. We hypothesized that nitrendipine would be efficacious in the treatment of hypertension in the elderly. We evaluated potential differences between nitrendipine and the commonly used drug hydrochlorothiazide (HCTZ). PATIENTS AND METHODS: The study was conducted as a double-blind randomized clinical trial of nitrendipine or HCTZ. Thirty hypertensive subjects over age 60 with a median sitting blood pressure greater than or equal to 95 mm of Hg were recruited into the study. A diastolic blood pressure with treatment of less than 95 mm Hg with a 5 mm Hg or greater decrease from baseline was considered a successful response. RESULTS: Nitrendipine decreased mean (+/- SEM) blood pressure from 163 +/- 3/102 +/- 1 to 142 +/- 2/89 +/- 2 mm Hg, and HCTZ decreased it from 164 +/- 4/102 +/- 1 to 143 +/- 5/91 +/- 2 mm Hg. A greater proportion of patients had a successful response with nitrendipine (81 percent) than with HCTZ (64 percent). The antihypertensive effect of nitrendipine twice daily appeared to be sustained for 24 hours. Blood pressure response to exercise was attenuated with both drugs. HCTZ caused gout, leg pains, muscle aches, hypokalemia, increased uric acid levels, and increased total cholesterol and triglyceride levels. Nitrendipine caused edema and tachycardia. CONCLUSION: Nitrendipine significantly reduces blood pressure with few side effects and no adverse metabolic effects, and offers a reasonable alternative for treating hypertension in the elderly.
Authors:
R L Byyny; M LoVerde; W Mitchell
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of medicine     Volume:  86     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-06     Completed Date:  1989-02-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  AIM; IM    
Affiliation:
Division of Internal Medicine, University of Colorado, Denver.
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MeSH Terms
Descriptor/Qualifier:
Aged
Blood Chemical Analysis
Blood Pressure / drug effects
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Hydrochlorothiazide / adverse effects,  therapeutic use*
Hypertension / drug therapy*
Male
Monitoring, Physiologic
Nitrendipine / adverse effects,  therapeutic use*
Placebos
Random Allocation
Chemical
Reg. No./Substance:
0/Placebos; 39562-70-4/Nitrendipine; 58-93-5/Hydrochlorothiazide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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