| Treatment of hypertension based on measurement of blood pressure variability: lessons from animal studies. | |
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MedLine Citation:
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PMID: 16900013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Blood pressure variability, a quantitative index for the spontaneous variation in blood pressure, has been proposed as a risk factor for end-organ damage and to determine the efficacy of hypertension treatment. RECENT FINDINGS: Animal studies indicate that blood pressure variability is as important as blood pressure level in determining end-organ damage, and that high blood pressure variability is associated with end-organ damage, including myocardial lesions, aortic hypertrophy, vascular remodeling and renal damage. Although the organ damage induced by high blood pressure variability was similar to that induced by hypertension, comparative studies in sinoaortic-denervated and spontaneously hypertensive rats revealed that aortic hypertrophy is a sensitive index of high blood pressure variability, and left ventricular hypertrophy is a sensitive index of high blood pressure level. The possible mechanisms for high blood pressure variability-induced end-organ damage include: direct endothelial lesions, renin-angiotensin system activation, inflammation initiation and cardiomyocyte apoptosis augmentation. Blood pressure variability reduction contributes importantly to the organ-protective effect of some antihypertensive drugs. SUMMARY: Although animal studies suggest some advantages in blood pressure variability measurements, clinical trials are necessary before the widespread use of blood pressure variability as a predictor of hypertensive organ damage and a new strategy for the treatment of hypertension. |
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Authors:
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Ding-Feng Su |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in cardiology Volume: 21 ISSN: 0268-4705 ISO Abbreviation: Curr. Opin. Cardiol. Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-08-10 Completed Date: 2006-12-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608087 Medline TA: Curr Opin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 486-91 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. dfsu@citiz.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology, therapeutic use* Apoptosis Blood Pressure / drug effects*, physiology Endothelium, Vascular / pathology Heart Diseases / etiology Hypertension / complications, drug therapy*, physiopathology Inflammation / pathology Kidney Diseases / etiology Rats Renin-Angiotensin System / physiology Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
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