Document Detail


Treatment of hypertension based on measurement of blood pressure variability: lessons from animal studies.
MedLine Citation:
PMID:  16900013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: Blood pressure variability, a quantitative index for the spontaneous variation in blood pressure, has been proposed as a risk factor for end-organ damage and to determine the efficacy of hypertension treatment. RECENT FINDINGS: Animal studies indicate that blood pressure variability is as important as blood pressure level in determining end-organ damage, and that high blood pressure variability is associated with end-organ damage, including myocardial lesions, aortic hypertrophy, vascular remodeling and renal damage. Although the organ damage induced by high blood pressure variability was similar to that induced by hypertension, comparative studies in sinoaortic-denervated and spontaneously hypertensive rats revealed that aortic hypertrophy is a sensitive index of high blood pressure variability, and left ventricular hypertrophy is a sensitive index of high blood pressure level. The possible mechanisms for high blood pressure variability-induced end-organ damage include: direct endothelial lesions, renin-angiotensin system activation, inflammation initiation and cardiomyocyte apoptosis augmentation. Blood pressure variability reduction contributes importantly to the organ-protective effect of some antihypertensive drugs. SUMMARY: Although animal studies suggest some advantages in blood pressure variability measurements, clinical trials are necessary before the widespread use of blood pressure variability as a predictor of hypertensive organ damage and a new strategy for the treatment of hypertension.
Authors:
Ding-Feng Su
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in cardiology     Volume:  21     ISSN:  0268-4705     ISO Abbreviation:  Curr. Opin. Cardiol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-10     Completed Date:  2006-12-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  486-91     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China. dfsu@citiz.net
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MeSH Terms
Descriptor/Qualifier:
Animals
Antihypertensive Agents / pharmacology,  therapeutic use*
Apoptosis
Blood Pressure / drug effects*,  physiology
Endothelium, Vascular / pathology
Heart Diseases / etiology
Hypertension / complications,  drug therapy*,  physiopathology
Inflammation / pathology
Kidney Diseases / etiology
Rats
Renin-Angiotensin System / physiology
Risk Factors
Chemical
Reg. No./Substance:
0/Antihypertensive Agents

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