Document Detail

Treatment of human spasticity with delta 9-tetrahydrocannabinol.
MedLine Citation:
PMID:  6271839     Owner:  NLM     Status:  MEDLINE    
Spasticity is a common neurologic condition in patients with multiple sclerosis, stroke, cerebral palsy or an injured spinal cord. Animal studies suggest that THC has an inhibitory effect on polysynaptic reflexes. Some spastic patients claim improvement after inhaling cannabis. We tested muscle tone, reflexes, strength and performed EMGs before and after double-blinded oral administration of either 10 or 5 mg THC or placebo. The blinded examiner correctly identified the trials in which the patients received THC in seven of nine cases. For the group, 10 mg THC significantly reduced spasticity by clinical measurement (P less than 0.01). Quadriceps EMG interference pattern was reduced in those four patients with primarily extensor spasticity. THC was administered to eight other patients with spasticity and other CNS lesions. Responses varied, but benefit was seen in three of three patients with "tonic spasms." No benefit was noted in patients with cerebellar disease.
D J Petro; C Ellenberger
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  21     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:    1981 Aug-Sep
Date Detail:
Created Date:  1982-01-09     Completed Date:  1982-01-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  413S-416S     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Multiple Sclerosis / physiopathology
Muscle Spasticity / drug therapy*
Reflex / drug effects
Tetrahydrocannabinol / adverse effects,  therapeutic use*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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