| Treatment of hirsutism with myo-inositol: a prospective clinical study. | |
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MedLine Citation:
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PMID: 18854115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to evaluate the effects of myo-inositol treatment in hirsute women; changes in lipid pattern and insulin sensitivity were also considered. Forty-six hirsute women were enrolled at the first Institute of Obstetrics and Gynecology and evaluated at baseline and after receiving myo-inositol therapy for 6 months. Body mass index (BMI), hirsutism, serum concentrations of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, apolipoprotein B, lipoprotein(a), serum adrenal and ovarian androgens, fasting glucose and insulin concentrations were evaluated. No changes in BMI were observed. The hirsutism decreased after therapy (P < 0.001). Total androgens, FSH and LH concentrations decreased while oestradiol concentrations increased. There was a slight non-significant decrease in total cholesterol concentrations, an increase in HDL cholesterol concentrations and a decrease in LDL cholesterol concentrations. No significant changes were observed in serum triglyceride, apolipoprotein B and lipoprotein(a) concentrations. Insulin resistance (P < 0.01), analysed by homeostasis model assessment, was reduced significantly after therapy. Administration of oral myo-inositol significantly reduced hirsutism and hyperandrogenism and ameliorated the abnormal metabolic profile of women with hirsutism. |
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Authors:
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M Minozzi; G D'Andrea; V Unfer |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 17 ISSN: 1472-6491 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-15 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 579-82 Citation Subset: IM |
Affiliation:
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First Institute of Obstetrics and Gynecology, University La Sapienza, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis, drug effects Cholesterol / blood Female Gonadal Steroid Hormones / blood Hirsutism / blood, drug therapy* Humans Inositol / therapeutic use* Insulin / blood Lipoproteins / blood Treatment Outcome Triglycerides / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Gonadal Steroid Hormones; 0/Lipoproteins; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol; 6917-35-7/Inositol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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