| Treatment of high fat diet induced type 2 diabetes in C57BL/6J mice by two medicinal plants used in traditional treatment of diabetes in the east of Algeria. | |
| | |
MedLine Citation:
|
PMID: 21094236 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
AIM OF THE STUDY: Hydro-alcoholic extracts of Centaurium erythraea Rafn (CE), Gentianaceae and Artemisia herba-alba Asso (AHA), Asteraceae, medicinal plants used in traditional treatment of diabetes in north-eastern Algeria, were tested in established type 2 diabetes induced with a standardized high fat diet (HFD) in mice. MATERIALS AND METHODS: After confirmation of diabetes (17th week), plant extracts were administered orally by gavage at a dose of 2g/kg daily for 18 weeks to male C57BL/6J mice fed HFD. Animals were weighed, food intake and plasma glucose measured weekly, insulin and lipid profile at study end. RESULTS: At 35 weeks, groups treated with AHA or CE vs. HFD control had a significant reduction in mean (±SD) fasting blood glucose concentrations (143.8±23.9 and 139.5±14.2 vs. 229.0±20.8mg/dL, p<0.05, respectively), triglyceride (18.9±11.1 and 16.0±6.5 vs. 62.8±18.3mg/dL, p<0.05), total cholesterol (1.2±0.1 and 1.2±0.3 vs. 1.8±1.1g/L, p<0.05) and serum insulin concentrations (1.7±0.7 and 0.9±0.7 vs. 3.3±14.3ng/mL, p<0.05). Plant extracts also markedly reduced insulin resistance as compared to HFD controls (AHA: 15.6±9.1, CE: 9.0±7.7 vs. HFD control 38.5±30.3, p<0.05). The plant extracts decreased calorie intake and had little effect on body weight or HDL-cholesterol. CONCLUSION: AHA has already been shown to have a antihyperglycaemic and antihyperlipidemic effect but this is the first demonstration of an effect of AHA and CE on established HFD-induced diabetes. |
| | |
Authors:
|
Nawel Hamza; Bénédicte Berke; Catherine Cheze; Raphaële Le Garrec; Régis Lassalle; Abdel-Nacer Agli; Philip Robinson; Henri Gin; Nicholas Moore |
Related Documents
:
|
2684716 - Prevention of diabetes in nod mice by injection of autoreactive t-lymphocytes. 15855336 - G(-) anaerobes-reactive cd4+ t-cells trigger rankl-mediated enhanced alveolar bone loss... 1583406 - Vitamin e supplementation reduces the incidence of diabetes but not insulitis in nod mice. 15448086 - A salen-manganese catalytic free radical scavenger inhibits type 1 diabetes and islet a... 7151656 - Glycosylated hemoglobin in the diagnosis of non-insulin-dependent diabetes mellitus. 15549416 - Allelic differences in a quantitative trait locus affecting insulin-like growth factor-... |
Publication Detail:
|
Type: Journal Article Date: 2010-11-19 |
Journal Detail:
|
Title: Journal of ethnopharmacology Volume: 133 ISSN: 1872-7573 ISO Abbreviation: J Ethnopharmacol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7903310 Medline TA: J Ethnopharmacol Country: Ireland |
Other Details:
|
Languages: eng Pagination: 931-3 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Département de Pharmacologie, Université Victor Segalen Bordeaux 2, Bordeaux, France; Département de Nutrition, INATAA, Université Mentouri de Constantine, Constantine, Algeria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Design of a composite drug delivery system to prolong functionality of cell-based scaffolds.
Next Document: Antituberculosis potential of some ethnobotanically selected Malaysian plants.