| Treatment of hepatitis C virus reinfection after liver transplantation. | |
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MedLine Citation:
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PMID: 16286889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Most liver transplant recipients become reinfected with hepatitis C virus after OLT followed by allograft dysfunction, transplant cirrhosis and graft failure in a significant proportion of patients. Both in the pre-emptive prophylactic setting and in the treatment setting sustained virological response rates are poor compared to the precirrhotic hepatitis state. Patients with significant hepatitis should be always treated before developing cirrhosis or even with early cirrhosis. After transplantation pegylated interferon in combination with ribavirin is the most successful treatment opportunity to date, however the best time point and treatment duration as well as doses for pegylated interferons and rebavirin have to be defined. |
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Authors:
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Jens Encke; Thomas Kraus; Arianeb Mehrabi; Wolfgang Stremmel; Peter Sauer |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Transplantation Volume: 80 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-11-15 Completed Date: 2006-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: S125-7 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany. jens_encke@med.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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therapeutic use Hepatitis C / prevention & control*, surgery* Humans Interferon Alfa-2b / therapeutic use Liver Transplantation* Recurrence Ribavirin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 36791-04-5/Ribavirin; 99210-65-8/Interferon Alfa-2b |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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