Document Detail


Treatment of haemophilia and related disorders in Britain and Northern Ireland during 1976-80: report on behalf of the directors of haemophilia centres in the United Kingdom.
MedLine Citation:
PMID:  6403138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A five year survey of the treatment of patients in the United Kingdom suffering from haemophilia and related disorders was carried out on behalf of the directors of haemophilia centres. The survey showed an increase in the number of patients receiving treatment from the centres, a substantial increase in the total amount of therapeutic materials used, and an increase in the average amount of factor VIII or factor IX used yearly per patient. Home treatment became established for severely affected patients and accounted for roughly half of the total amount of material used. Study of the acquisition of factor VIII or factor IX antibodies (inhibitors) in patients with haemophilia A or haemophilia B showed no increase in antibodies during the survey period, despite the increased use of factor VIII and factor IX concentrates. The occurrence of acute hepatitis in treated patients was also studied and no increased incidence was observed. A near normal median expectation of life in patients with severe haemophilia A was found.
Authors:
C R Rizza; R J Spooner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  286     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  929-33     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Factor IX / therapeutic use
Factor VIII / therapeutic use
Great Britain
Hemophilia A / complications,  mortality,  therapy*
Hemophilia B / mortality,  therapy*
Hepatitis / etiology
Heterozygote
Home Care Services / utilization
Humans
Life Expectancy
Middle Aged
von Willebrand Diseases / therapy
Chemical
Reg. No./Substance:
9001-27-8/Factor VIII; 9001-28-9/Factor IX
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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