Document Detail

Treatment of generalized tardive dystonia with clozapine.
MedLine Citation:
PMID:  18827758     Owner:  NLM     Status:  MEDLINE    
Tardive dystonia is a syndrome of sustained muscle contractions, frequently causing twisting and repetitive movements or abnormal postures, associated with prolonged exposure to antipsychotics. We report a case of a 35-year-old patient with schizophrenia who developed a generalized form of tardive dystonia after switching of clozapine to risperidone treatment that persisted after switch to olanzapine and during the period while treatment with an antipsychotic was discontinued. It was successfully managed with reintroduction of clozapine. The case may represent the first report of generalized tardive dystonia while taking risperidone. The possible pathophysiological bases of the disorder are discussed. The goal of our report is to emphasize that an adequate trial of clozapine is a worthwhile option in the cases of tardive dystonia, even where discontinuation of antipsychotics was unsuccesful.
Branka Aukst-Margetić; Branimir Margetić
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Psychiatria Danubina     Volume:  20     ISSN:  0353-5053     ISO Abbreviation:  Psychiatr Danub     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2008-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9424753     Medline TA:  Psychiatr Danub     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  329-31     Citation Subset:  IM    
Neuropsychiatric hospital "Dr. Ivan Barbot" Popovaca, Croatia.
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MeSH Terms
Antipsychotic Agents / adverse effects*,  therapeutic use*
Clozapine / therapeutic use*
Dyskinesia, Drug-Induced / drug therapy*,  etiology,  physiopathology
Dystonic Disorders / chemically induced*,  drug therapy,  physiopathology
Follow-Up Studies
Psychiatric Status Rating Scales
Receptors, GABA / physiology
Receptors, Muscarinic / physiology
Risperidone / adverse effects,  therapeutic use
Reg. No./Substance:
0/Antipsychotic Agents; 0/Receptors, GABA; 0/Receptors, Muscarinic; 106266-06-2/Risperidone; 5786-21-0/Clozapine

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