| Treatment of generalized tardive dystonia with clozapine. | |
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MedLine Citation:
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PMID: 18827758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tardive dystonia is a syndrome of sustained muscle contractions, frequently causing twisting and repetitive movements or abnormal postures, associated with prolonged exposure to antipsychotics. We report a case of a 35-year-old patient with schizophrenia who developed a generalized form of tardive dystonia after switching of clozapine to risperidone treatment that persisted after switch to olanzapine and during the period while treatment with an antipsychotic was discontinued. It was successfully managed with reintroduction of clozapine. The case may represent the first report of generalized tardive dystonia while taking risperidone. The possible pathophysiological bases of the disorder are discussed. The goal of our report is to emphasize that an adequate trial of clozapine is a worthwhile option in the cases of tardive dystonia, even where discontinuation of antipsychotics was unsuccesful. |
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Authors:
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Branka Aukst-Margetić; Branimir Margetić |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Psychiatria Danubina Volume: 20 ISSN: 0353-5053 ISO Abbreviation: Psychiatr Danub Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-01 Completed Date: 2008-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9424753 Medline TA: Psychiatr Danub Country: Croatia |
Other Details:
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Languages: eng Pagination: 329-31 Citation Subset: IM |
Affiliation:
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Neuropsychiatric hospital "Dr. Ivan Barbot" Popovaca, Croatia. branka.aukst-margetic@zg.t-com.hr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipsychotic Agents / adverse effects*, therapeutic use* Clozapine / therapeutic use* Dyskinesia, Drug-Induced / drug therapy*, etiology, physiopathology Dystonic Disorders / chemically induced*, drug therapy, physiopathology Follow-Up Studies Hospitalization Humans Male Psychiatric Status Rating Scales Receptors, GABA / physiology Receptors, Muscarinic / physiology Risperidone / adverse effects, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 0/Receptors, GABA; 0/Receptors, Muscarinic; 106266-06-2/Risperidone; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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