Document Detail

Treatment of gastritis in cheetahs (Acinonyx jubatus).
MedLine Citation:
PMID:  9365937     Owner:  NLM     Status:  MEDLINE    
Three cheetahs (Acinonyx jubatus) had a clinical history of chronic spiral bacteria-associated gastritis and three cheetahs had no clinical history of gastritis. Gastric biopsies were obtained from all six cheetahs prior to treatment for gastritis and 3 wk and 1 yr posttreatment. The cheetahs were treated with tetracycline hydrochloride 500 mg p.o. q.i.d., metronidazole 250 mg p.o. q.i.d., and bismuth subsalicylate 300 mg p.o. q.i.d. Each drug was administered concurrently for 7 days. Following this treatment, each cheetah was maintained on 300 mg bismuth subsalicylate p.o. s.i.d. for 1 yr. The three cheetahs with a history of gastritis were culture positive for Helicobacter acinonyx and remained positive during the entire study. The three cheetahs with no clinical history of gastritis were culture negative for H. acinonyx, but gastric biopsies revealed Gastrospirillum-like bacteria (tentatively named Helicobacter heilmannii) pretreatment. Gastric biopsies were negative for H. heilmannii on subsequent examinations. Although the treatment did not eradicate H. acinonyx, it did provide symptomatic relief from the vomiting, anorexia, and weight loss associated with clinical gastritis. The use of endoscopically guided gastric mucosal biopsies for urease testing and histopathologic examination of Warthin-Starry-stained sections is a sensitive and specific method of diagnosing spiral bacteria-associated gastritis. Treatment of spiral bacteria-associated gastritis in cheetahs should include the rational use of antibiotics (tetracycline or amoxicillin and metronidazole), bismuth compounds, and omeprazole and evaluation of husbandry methods to reduce stress.
R F Wack; K A Eaton; L W Kramer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians     Volume:  28     ISSN:  1042-7260     ISO Abbreviation:  J. Zoo Wildl. Med.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8915208     Medline TA:  J Zoo Wildl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  260-6     Citation Subset:  IM    
Columbus Zoo, Powell, Ohio 43065, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Antitrichomonal Agents / therapeutic use
Biopsy / veterinary
Bismuth / therapeutic use
Dose-Response Relationship, Drug
Drug Therapy, Combination
Gastric Mucosa / microbiology,  pathology
Gastritis / drug therapy,  etiology,  veterinary*
Gram-Negative Bacterial Infections / drug therapy,  veterinary
Helicobacter / isolation & purification
Helicobacter Infections / drug therapy,  veterinary
Lymphocytes / microbiology,  pathology
Metronidazole / therapeutic use
Organometallic Compounds / therapeutic use
Prospective Studies
Salicylates / therapeutic use
Sensitivity and Specificity
Tetracycline / therapeutic use
Time Factors
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antitrichomonal Agents; 0/Organometallic Compounds; 0/Salicylates; 14882-18-9/bismuth subsalicylate; 443-48-1/Metronidazole; 60-54-8/Tetracycline; 7440-69-9/Bismuth

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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