Document Detail

Treatment of gastric ulcer with enprostil.
MedLine Citation:
PMID:  3092660     Owner:  NLM     Status:  MEDLINE    
This study evaluated the efficacy of two dosage levels of enprostil in 129 patients with gastric ulcer disease. Patients with endoscopically diagnosed gastric ulcer were randomly assigned to receive enprostil 70 micrograms, enprostil 35 micrograms, or a matching placebo capsule twice daily for six weeks. Ulcer healing rates were similar in all treatment groups after two weeks of therapy, but began to show some differences in favor of the enprostil treatment groups after four weeks. Greater differences were noted after six weeks of therapy, with healing rates of 70 percent in the 70-micrograms enprostil group, 82 percent in the 35-micrograms enprostil group, and 50 percent in the placebo group. The six-week healing rate in the 35-micrograms enprostil group was significantly greater than the placebo rate (p = 0.005). Comparison of healing rates in the active treatment groups and the placebo group after six weeks of therapy showed a correlation between therapeutic effect and ulcer size at baseline. This trend is illustrated by a 24 percent difference between the 35-micrograms enprostil group and the placebo group among patients with small (3 to 9 mm) ulcers, compared with a 46 percent difference between these two groups among patients with large (20 to 30 mm) ulcers. Thus, the effectiveness of enprostil is more readily demonstrable in patients with larger ulcers.
H Navert
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of medicine     Volume:  81     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-10-06     Completed Date:  1986-10-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  AIM; IM    
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MeSH Terms
Clinical Trials as Topic
Middle Aged
Prostaglandins E, Synthetic / administration & dosage,  adverse effects,  therapeutic use*
Random Allocation
Stomach Ulcer / drug therapy*
Time Factors
Reg. No./Substance:
0/Prostaglandins E, Synthetic; 73121-56-9/Enprostil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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